Item type:Thesis, Open Access

Perfusionsmuster peripherer organisierender Pneumonien im kontrastmittelunterstützten Ultraschall und ihre Korrelation mit immunhistochemisch detektierten Gefäßmustern

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Date

2025-06-04

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Philipps-Universität Marburg
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Abstract

The aim of the present study was to describe the perfusion patterns of peripheral organizing pneumonia detected by contrast-enhanced ultrasound and their correlation with the vascularization patterns represented by immunhistochemical CD34 endothelial staining. Therefore, the data of biopsies, B-mode lung ultrasound and contrast-enhanced ultrasound of 38 patients with histopathologically confirmed organizing pneumonia were analyzed. An unspecific perfusion pattern on contrast-enhanced ultrasound was shown. A bronchialarterial, hypoechogeneous, inhomogeneous perfusion pattern with partly avascular areas as well as a rapid washout in 50% of the cases was predominant. In immunhistochemical CD34 endothelial staining all biopsies showed a disorganized and chaotic vascularization pattern due to bronchialarterial neoangiogenesis. Additionally, a few of the biopsies showed a pulmonalarterial vascularization pattern as well as avascular areas. The results show that a pulmonal arterial perfusions pattern or a late washout cannot exclude bronchialarterial neoangiogenesis but the bronchialarterial perfusion of the lesions is covered by the early pulmonalarterial perfusion pattern. Caused by the fact that in peripheral lung lesions the features of chronic inflammatory processes as well as malignant processes are similar with regard to bronchialarterial neoangiogenesis the histopathological investigation for knowledge of cause and dignity of the lesions is still warranted.

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Dates
Created: 2025Issued: 2025-06-04Updated: 2025-06-04
DOI
https://doi.org/10.17192/z2025.0287
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
DFG-subjects
NeoangiogeneseCD-34UltraschallCEUSperiphere organisierende Pneumoniehistopathologische Korrelation
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2025.0287
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Mohr, Charlotte Gabriele Luise: Perfusionsmuster peripherer organisierender Pneumonien im kontrastmittelunterstützten Ultraschall und ihre Korrelation mit immunhistochemisch detektierten Gefäßmustern. : Philipps-Universität Marburg 2025-06-04. DOI: https://doi.org/10.17192/z2025.0287.

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