open_UMR

Aaron Beller

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Welcome to open_UMR!

Open_UMR is a cross faculty publication hub. We collect scientific publications, resources, research data and software from members of Philipps-University Marburg and make it openly accessible. To ensure high standards of quality and re-usability, submissions to open_UMR are subject to curation.

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Recent Submissions

Open Access
Preclinical performance of a novel dental implant design reducing mechanical stress in cortical bone
(MDPI) Karl, Matthias
This animal study compared the healing performance of a novel implant design characterized by a shift in thread geometry and core diameter with two different surfaces with that of an apically tapered implant. Test Bioactive (n = 9), Test Porous (n = 7) and Control (n = 8) implants were placed in the mandibles of minipigs. Following healing, bone samples were harvested for determining bone-to-implant contact (BIC) and marginal bone loss (MBL). Comparative statistics were based on Levene’s test, Shapiro–Wilk tests, the Kruskal–Wallis test and Wilcoxon tests with Holm correction (α = 0.05). The mean undersizing of the osteotomy was 0.15 mm for Control, while in the test groups 0.33 mm and 0.34 mm were calculated. Insertion torques ranged from 61.5 Ncm (Control) to 76.1 Ncm (Test Bioactive). Maximum BIC was seen in Test Porous with 55.83%, while Test Bioactive showed only 48.11%. MBL was 4.1 mm in Test Bioactive, while Test Porous and Control exhibited 2.8 mm. No significant differences between the implant groups were observed (p > 0.05). Despite greater undersizing, the novel implant type performed comparably to the established Control implants. The rougher surface of the bioactive implants increased the insertion torque and led to more MBL.
Open Access
The perceived burden of working with traumatized youth: construction andpsychometric investigation of the Trauma Professionals’ Burden Scale (TPBS)
(Taylor & Francis) Fuchs, Josephine Maya; Szota, Katharina; Christiansen, Hanna; van der Meer, Anna Swantje
Background: It is assumed that providing trauma-informed care for children and adolescentsis a major challenge for professionals in child and youth welfare, psychiatric clinics andpsychotherapy practices, yet studies are scarce. This is partly due to the fact that validinstruments that capture the specific stress caused by working with traumatized youths aremissing. Our study aims to present the construction and results of the psychometricinvestigation of a scale that addresses the concerns, strains and needs of professionals, theTrauma Professionals’ Burden Scale (TPBS).Methods: In our cross-sectional survey with youth psychotherapists, welfare professionals andpsychiatric care staff (N = 834), the psychometric properties of the TPBS were examined usingstandard item and reliability analyses, exploratory factor analysis and confirmatory factoranalysis (CFA). Convergent validity was assessed by testing the hypothesis that two TPBSsubscales show high positive correlations with two established scales.Results: After deletion of eleven items, the remaining items of the TPBS show gooddiscriminatory power, allowing to discriminate between participants with high or low scores,and high factor loadings. CFA results indicate fair model fit (RMSEA = .081, CFI = .81). Internalconsistencies of the subscales range from ω = .76 to ω = .89. The expected correlations withthe established scales are confirmed. A six-item short scale was created, showing excellentmodel fit (RMSEA = .047, CFI = .99) and good internal consistency (ω = .88).Conclusions: Although further validating research is required, the present study supports thepsychometric validity of the TPBS enabling to assess professionals’ stress associated withproviding trauma-informed care for youth.
Open Access
Prevalence of and factors associated with hypertension in children and adolescents as observed by German pediatricians—a case–control study
(MDPI) Kostev, Karel
Background: Blood pressure elevation in children is an important health concern. The extent to which hypertension is diagnosed in German pediatric practices is not yet known. The aim of this study is, therefore, to examine the prevalence of hypertension diagnosis in children and adolescents treated in pediatric practices, as well as the factors associated with hypertension in this population. Methods: This retrospective case–control study used electronic medical records from 258 primary care pediatricians in Germany and included children and adolescents aged 0–17 years with an initial documented diagnosis of primary hypertension between January 2005 and December 2023. Hypertension patients were matched 1:5 with non-hypertension patients by age and sex. Conditional multivariable logistic regression models were used to estimate the association of chronic diseases and therapies with a risk of hypertension. Results: After 1:5 matching, the present study included 7482 children and adolescents with hypertension, and 37,410 controls without hypertension. The average prevalence of hypertension was 0.12% and the incidence was 1.24 cases per 1000 person-years, both increasing with age. In the multivariable regression analysis, a significant positive association was observed between hypertension and ten disorders including obesity (odds ratio, OR: 6.91; 95% confidence intervals, CI: 6.28–7.60), type 1 diabetes mellitus (OR: 2.85; 95% CI: 2.13–3.82), dyslipidemia (OR: 1.99; 95% CI: 1.46–2.72), chronic bronchitis (OR: 1.63; 95% CI: 1.39–1.90), hypothyroidism (OR: 1.62; 95% CI: 1.30–2.02), migraine (OR: 1.52; 95% CI: 1.17–1.98), ADHD (OR: 1.45; 95% CI: 1.28–1.65), scoliosis (OR: 1.40; 95% CI: 1.13–1.73), chronic rhinitis (OR: 1.31; 95% CI: 1.14–1.50), and reaction to severe stress and adjustment disorders (OR: 1.31; 95% CI: 1.04–1.65). Furthermore, paracetamol prescription was positively associated with hypertension risk (OR: 1.68; 95% CI: 1.41–2.00). Conclusions: The significant associations between hypertension and chronic disorders, particularly obesity, underscore the need for early prevention strategies. Prospective studies are needed to confirm these associations. Similarly, pathophysiological and mechanistic explanations for the associations identified need to be explored and verified in properly designed studies.
Open Access
Improved photodynamic therapy of hepatocellular carcinoma via surface-modified protein nanoparticles
(MDPI) Abdelsalam, Ahmed M.; Amin , Muhammad Umair; Engelhardt, Konrad H.; Balash, Amir; Preis, Eduard; Bakowsky, Udo
Background: Photodynamic therapy (PDT) has evolved as a reliable therapeutic modality for cancer. However, the broad application of the technique is still limited because of poor bioavailability and the non-selective distribution of photosensitizers within host tissues. Herein, zein, a natural corn protein, was functionalized with glycyrrhetinic acid (GA) and polyethylene glycol (Z-PEG-GA) as a targeting platform for liver cancer cells. Parietin, as novel photosensitizer, was successfully encapsulated into zein via nanoprecipitation and used for the therapy of hepatocellular carcinoma. Methods: The in vitro phototoxicity of ZPEG-GA nanoparticles and their non-functionalized control (Z-PEG) were assessed against hepatocellular carcinoma (HepG2 cells) and the In vivo biodistribution was determined in an adult male CD-1 Swiss albino mice model. Results: The formulated Z-PEG and Z-PEG-GA showed spherical shapes with average sizes of 82.8 and 94.7 nm for unloaded nanoparticles, respectively, and 109.7 and 111.5 nm for loaded nanoparticles carrying more than 70% of parietin, and Quantum yield measurements show that parietin’s photodynamic potential is conserved. Moreover, parietin-loaded Z-PEG-GA exhibited three-fold higher toxicity against liver cancer cells than its non-functionalized control and attained more than an eleven-fold enhancement in the generated intracellular reactive oxygen species (ROS) at a 9 J/cm2 radiant exposure. The generated intracellular ROS led to mitochondrial disruption and the release of cytochrome c. In vivo biodistribution studies revealed that fluorescence signals of Z-PEG-GA can persist in the excised animal liver for up to 24 h post-administration. Conclusions: Consequently, tailored zein can hold great potential for delivering several hydrophobic photosensitizers in anticancer PDT.
Open Access
Umfragedaten zur Open-Access-Umfrage der UB Marburg 2024
(Philipps-Universität Marburg) Riedl, Lydia; Müllerleile, Tobias; Massenberg, Antonia (Toni); Löhden, Eike Martin
Hier veröffentlichen wir die Daten zur Umfrage über Open-Access-Publikationspraktiken an der Philipps-Universität Marburg. Die Umfrage wurde per RedCap durchgeführt, die hier publizierte Rohdatentaelle und das dazugehörige Codebook wurden direkt aus RedCap exportiert. Das entsprechende GitLab-Repo zur interaktiven Version (JupyterBook) ist in open_UMR als Software veröffentlicht und per relations mit dieser Publikation verknüpft. Der Preprint zur Umfrage sind ebenfalls in open_UMR veröffentlicht und per relations mit dieser Publikation verknüpft. In dieser Publikation enthalten sind: OpenAccessUmfrage_DATA_2024-02-20_1219.csv - die Rohdaten aus der Umfrage. OpenAccessUmfrage_instrument.csv - Codebook zur Umfrage mit Zuordnung der Werte aus der Rohdatentabelle.