Transdiagnostische Psychopathologie-Dimensionen und ihre Assoziationen zur funktionellen Resting-State-Konnektivität
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Abstract
Mental disorders are prevalent and lead to considerable personal and societal challenges, largely due to the loss of quality-adjusted life years and the decline in both physical and mental functioning. Despite substantial research efforts, our understanding of the underlying causes and neurobiological mechanisms remains incomplete. One contributing factor may be the reliance on categorical diagnostic systems, such as the ICD and DSM, which define mental disorders according to strict diagnostic categories. These frameworks are often criticised for their high rates of comorbidity, rigid symptom thresholds, significant overlap between disorders, and heterogeneity within diagnostic groups. These limitations have driven the development of dimensional and transdiagnostic approaches to capture neurobiological correlates beyond categorical criteria.
This study aimed to identify cross-diagnostic correlates of functional resting-state connectivity associated with transdiagnostic symptom dimensions. A seed-to-voxel analysis was performed using the CONN Toolbox to assess the associations between functional resting-state connectivity and five psychopathological dimensions — depression, negative syndrome, positive formal thought disorder, paranoid-hallucinatory syndrome, and increased appetite — in a transdiagnostic cohort. The sample included patients who met the diagnostic criteria of the DSM-IV for major depressive disorder, bipolar disorder, or schizophrenia-spectrum disorder. Structural T1-weighted and functional resting-state magnetic resonance imaging data were acquired using 3-tesla magnetic resonance imaging scanners and preprocessed in the CONN Toolbox. Interaction analyses (diagnosis category x psychopathological factor) were conducted to determine whether resting-state connectivity associations were driven by DSM-IV diagnoses.
The results showed that individual psychopathological dimensions were associated with specific resting-state connectivity patterns: Positive formal thought disorder was associated with dysconnectivity between the right superior temporal gyrus and the anterior cingulate, as well as hypoconnectivity with the central operculum and the caudate nucleus. Paranoid-hallucinatory syndrome was linked to hypoconnectivity between the planum temporale and the left inferior temporal gyrus and hyperconnectivity with the right middle frontal gyrus. None of the significant connectivity associations interacted with DSM-IV diagnoses. No significant associations were found for the dimensions of depression, negative syndrome, or increased appetite.
These findings indicate cross-diagnostic associations between functional resting-state connectivity and symptoms from the positive symptom spectrum. Both positive formal thought disorder and paranoid-hallucinatory syndrome were associated with dysconnectivity in temporal structures of the language network, suggesting neurobiological mechanisms involved in the development of these symptoms, independent of categorical diagnoses.
The results support the existence of transdiagnostic neurobiological correlates that extend beyond traditional categorical diagnostic criteria. This work aligns with dimensional research approaches in psychiatry, highlighting the potential of this perspective to enhance understanding of the pathophysiology of mental disorders and to inspire new avenues for innovative diagnostic and therapeutic strategies.
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Issued: 0008-12-25
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FB20:Medizin
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de
Keywords
functional resting-state connectivitydimensionale PsychopathologieTransdiagnostischfunktionelle Resting-State Konnektivität
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Keunecke, Luca Mira: Transdiagnostische Psychopathologie-Dimensionen und ihre Assoziationen zur funktionellen Resting-State-Konnektivität. : 0008-12-25.
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Except where otherwised noted, this item's license is described as Attribution 4.0 International