Item type:Thesis, Open Access

Contributions to the Asymmetric Synthesis of Octahedral Ruthenium(II) Complexes and to Bioactive Hexacoordinate Silicon Complexes

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2014-11-26

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Philipps-Universität Marburg
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Abstract

This thesis mainly includes two parts: one is about the asymmetric synthesis of octahedral ruthenium complexes, and the other one is about the synthesis and investigation of the biological activities of octahedral silicon complexes. In the first part of this thesis, we started with a straightforward and economical method for the asymmetric synthesis of mononuclear ruthenium(II) complexes [Ru(pp)(pp’)(pp’’)](PF6)2 (pp = polypyridyl ligands) by using the readily available racemic starting material [Ru(pp)(pp’)Cl2] together with the natural amino acid L-proline. Next, we initially studied the asymmetric synthesis of dinuclear octahedral ruthenium(II) complexes, and synthesized an enantiomerically enriched dinuclear ruthenium complex for the first time. In the second part of this thesis, we developed the syntheses of hydrolytically stable octahedral silicon complexes, such as silicon arenediolate complexes, silicon arenediaminate complexes, enantiopure silicon BINOLate complexes, and silicon-ruthenium sandwich complexes. Furthermore, we investigated the biological activities of the octahedral silicon complexes and found that the silicon arenediolate complexes could be used as efficient DNA intercalators, while the bulky silicon-ruthenium sandwich complexes could detect mismatched DNA and serve as insertors.

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Dates
Created: 2014Issued: 2014-11-26
DOI
https://doi.org/10.17192/z2014.0243
Faculty
Fachbereich Chemie
Publisher
Philipps-Universität Marburg
Language
eng
Data types
DoctoralThesis
Keywords
Silicon ComplexesAsymmetric SynthesisRuthenium
DFG-subjects
Rutheniumasymmetrische SyntheseSilicium-Komplexe
DDC-Numbers
540
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2014.0243
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Fu, Chen (1064146368): Contributions to the Asymmetric Synthesis of Octahedral Ruthenium(II) Complexes and to Bioactive Hexacoordinate Silicon Complexes. : Philipps-Universität Marburg 2014-11-26. DOI: https://doi.org/10.17192/z2014.0243.

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