Item type:Thesis, Open Access

Carbonyl Reductases and Pluripotent HydroxysteroidDehydrogenases of the Short-Chain Dehydrogenase/ReductaseSuperfamily:Structural Aspects of Oligomerization in 3alpha-HydroxysteroidDehydrogenase /Carbonyl Reductase from Comamonas testosteroni:New Approaches for efficient Protein Design

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Date

2009-10-08

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Philipps-Universität Marburg
DOI

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Abstract

Carbonyl reduction of aldehydes, ketones and quinones to their corresponding hydroxy de-rivatives plays an important role in the phase-I metabolism of many endogenous (biogenic aldehydes, steroids, prostaglandins, reactive lipid peroxidation products) and xenobiotic (pharmacologic drugs, carcinogens, toxicants) compounds. Carbonyl-reducing enzymes are grouped into two large protein superfamilies, the aldo-keto reductases (AKR) and the short-chain dehydrogenases/reductases (SDR). Whereas aldehyde reductase and aldose reductase are AKRs, several forms of carbonyl reductase belong to the SDRs. In addition, there exist a variety of pluripotent hydroxysteroid dehydrogenases (HSDs) of both superfamilies which specifically catalyze the oxidoreduction at different positions of the steroid nucleus, and which also catalyze rather non-specifically the reductive metabolism of a great number of non-steroidal carbonyl compounds. The present review summarizes recent findings on car-bonyl reductases and pluripotent HSDs of the SDR protein superfamily.

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Dates
Created: 2009Issued: 2009-10-08Updated: 2022-03-28
Faculty
Fachbereich Biologie
Language
eng
Data types
DoctoralThesis
Keywords
RöntgenstrukturMolekulardynamikSDRDrug DesignHydroxysteroiddehydrogenaseSimulationMolecular dynamicSDR3alpha HSD/CR
DFG-subjects
ModellierungCarbonyl-ReductaseHydroxysteroid-DehydrogenasenMolekulardynamik
DDC-Numbers
570
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2009.0563
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Hoffmann-Geim, Frank (139118586): Carbonyl Reductases and Pluripotent HydroxysteroidDehydrogenases of the Short-Chain Dehydrogenase/ReductaseSuperfamily:Structural Aspects of Oligomerization in 3alpha-HydroxysteroidDehydrogenase /Carbonyl Reductase from Comamonas testosteroni:New Approaches for efficient Protein Design. : Philipps-Universität Marburg 2009-10-08. DOI: https://doi.org/10.17192/z2009.0563.

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This item has been published with the following license: In Copyright