Vorhofflimmern bei obstruktiver und zentraler Schlafapnoe: Eine Analyse von Prävalenz und möglichen Einflussgrößen
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Abstract
Atrial fibrillation is the most common sustained arrhythmia and represents a growing cardiovascular health burden, particularly in the context of an aging population. The increasing prevalence of atrial fibrillation can be attributed not only to improved diagnostic strategies but also to the growing burden of associated risk factors such as obesity, arterial hypertension, and other cardiovascular diseases. In addition, sleep-disordered breathing has emerged as a relevant risk factor, with multiple studies demonstrating an increased prevalence of atrial fibrillation in affected individuals.
In this retrospective study, data from 1,402 patients who underwent inpatient polysomnography at the University Hospital Marburg between June 2021 and May 2022 were analyzed. After applying predefined exclusion criteria, 1,166 patients were included in the final analysis. In addition to clinical parameters, particular emphasis was placed on determining the prevalence of atrial fibrillation. Statistical analyses were performed using univariate and multivariate approaches, including logistic regression models. The overall prevalence of atrial fibrillation in the study population was 9%, markedly higher than the estimated prevalence of approximately 3% in the general population. Subgroup analysis revealed a significant difference between patients with obstructive and central sleep apnea: while the prevalence of atrial fibrillation was 6% in patients with obstructive sleep apnea, it reached 39% in those with central sleep apnea. Furthermore, cardiovascular risk factors (arterial hypertension, diabetes mellitus) and comorbidities (chronic kidney disease, anemia) were significantly more prevalent in the group with central sleep apnea. In multivariable regression analysis, both the presence of central sleep apnea and increasing age emerged as independent predictors of atrial fibrillation. In contrast, obesity, arterial hypertension, and diabetes mellitus showed a non-significant trend toward an increased risk of atrial fibrillation.
The present study confirms the association between sleep-disordered breathing and atrial fibrillation as previously described in the literature. It further emphasizes a particularly strong relationship between sleep-disordered breathing, especially central sleep apnea, and atrial fibrillation. Given the substantial disease burden, targeted screening for atrial fibrillation in patients with sleep-disordered breathing appears warranted to facilitate early and individualized therapeutic interventions that may reduce morbidity and mortality. Prospective studies employing standardized diagnostic approaches and structured cardiological follow-up are needed to further validate the clinical relevance of these findings.
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Issued: 2026-03-13
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FB20:Medizin
Language
de
Keywords
Schlafbezogene AtmungsstörungenObstruktive SchlafapnoeZentrale SchlafapnoeVorhofflimmern
DFG-subjects
2.22-13 - Pneumologie, Thoraxchirurgie
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Mausinbaev, Timo: Vorhofflimmern bei obstruktiver und zentraler Schlafapnoe: Eine Analyse von Prävalenz und möglichen Einflussgrößen. : 2026-03-13. DOI: https://doi.org/10.17192/openumr/582.
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This item has been published with the following license: In Copyright