This cumulative dissertation comprises two scientific studies investigating the use of
advanced high-precision radiotherapy techniques for complex tumors of the central
nervous system and skull base. Both studies were conducted at the University Hospital
Marburg and evaluated the efficacy and safety of photon and particle therapy. The first
publication analyzed patients with WHO Grade II/III meningiomas treated with photon
or particle radiotherapy. The study demonstrated excellent local control (72% at 5 years)
and overall survival (>99% at 8 years) with minimal toxicity. Particle therapy was
associated with lower rates of late side effects, particularly headache and vertigo. The
second study focused on the management of locally advanced SNC using a combined
carbon ion boost and IMRT approach. This multimodal regimen achieved significantly
better local control and survival in the primary treatment group compared to re-irradiation
cases. Acute toxicities such as mucositis and xerostomia were common but reversible,
and no severe late adverse effects occurred. In conclusion, both studies highlight that
modern high-precision radiotherapy, particularly particle therapy, provides an effective
and safe treatment option for aggressive and anatomically challenging tumors. The results
contribute to refining future treatment strategies and improving patients’ quality of life.
Sheikhzadeh, Fatima Frosan: Moderne Hochpräzisionsstrahlentherapie bei Tumoren des ZNS und der Schädelbasis – Ergebnisse und Toxizitätsanalyse zweier klinischer Studien. : 0026-02-23.
