Item type:Thesis, Open Access

Pharmakologische Charakterisierung der Wirkungen von Glukokortikoiden auf die Atmungskette und die ATP-Synthese in adrenokortikotrophen Hypophysenzellen (AtT20)

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Date

2005-12-13

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Philipps-Universität Marburg
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Abstract

In order to characterize effects of the glucocorticoid dexamethasone on parameters of mitochondrial energy metabolism, we conducted in vitro trials, using a murine AtT20 cell line. The experimental parameters were the ATP-concentration and a mitochondrial function test (EZ4U). After longterm incubation (>30 min.), we found suppressing effects on the experimental parameters. After shortterm incubation (≤30 min.), the effects were either increasing or suppressing the experimental parameters, and dose-dependent. The shortterm effects in the mitochondrial function test could not be blocked by the glucocorticoid-receptor-antagonist RU38486. The effects observed are presumably nongenomic in nature and could be involved in regulation or impairment of the hypothalamic-pituitary-adrenocortical axis.

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Dates
Created: 2005Issued: 2005-12-13Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2005.0681
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
GlucocorticoidsMitochondria
DFG-subjects
MitochondriumGlucocorticosteroide
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2005.0681
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Heinrich, Christina: Pharmakologische Charakterisierung der Wirkungen von Glukokortikoiden auf die Atmungskette und die ATP-Synthese in adrenokortikotrophen Hypophysenzellen (AtT20). : Philipps-Universität Marburg 2005-12-13. DOI: https://doi.org/10.17192/z2005.0681.

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