Item type:Thesis, Open Access

Knospung-steuernde Gene in Hydra vulgaris: Ein evolutionsgeschichtlich alter FGFR kontrolliert die Knopsenablösung

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Date

2006-07-20

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Philipps-Universität Marburg
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Abstract

By expression screening we have identified a fibroblast growth factor receptor (FGFR)-like tyrosine kinase (Kringelchen) from Hydra vulgaris. The highly dynamic expression pattern during budding suggested that kringelchen plays an important role during the asexual propagation of Hydra. After treatment with SU5402, a specific inhibitor of FGFR activity, as well as with antisense-oligonucleotides against kringelchen, polyps developed a branched phenotype. Bud detachment failed. This led to the hypothesis that Kringelchen is essential for bud detachment. The detailed analysis of kringelchen expression pattern during head- and foot regeneration as well as during development of cell aggregates furthermore suggests an involvement in general patterning and axis formation. The isolation of a cDNA-fragment encoding an FGF-like protein in Hydra indicates that Kringelchen binds to FGFs.

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Dates
Created: 2006Issued: 2006-07-20Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2006.0130
Faculty
Fachbereich Biologie
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
FGFBuddingPatterningHydra vulgaris
DFG-subjects
Braune HydraFibroblastenwachstumsfaktorMusterbildungKnospung
DDC-Numbers
570
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2006.0130
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Sudhop, Stefanie: Knospung-steuernde Gene in Hydra vulgaris: Ein evolutionsgeschichtlich alter FGFR kontrolliert die Knopsenablösung. : Philipps-Universität Marburg 2006-07-20. DOI: https://doi.org/10.17192/z2006.0130.

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This item has been published with the following license: In Copyright