Item type:Article, Open Access

The Orexin System and Its Impact on the Autonomic Nervous and Cardiometabolic System in Post-Acute Sequelae of COVID-19

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biomedicines-13-00545.pdf (1.96 MB)

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MDPI

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Abstract

Orexins (OXs) are critical for regulating circadian rhythms, arousal, appetite, energy metabolism, and electrolyte balance, affecting both the autonomic nervous system (ANS) and the cardiovascular system (CVS). Disruption of the OX system can result in symptoms similar to those observed in post-acute sequelae of COVID-19 (PASC). This review emphasizes the adverse effects of OX dysregulation on autonomic and cardiometabolic functions in patients with PASC. Additionally, we highlight the potential of anti-OX therapies to provide neuroprotective, anti-inflammatory, and immunoregulatory benefits, offering hope for alleviating some of the debilitating symptoms associated with PASC.

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Is version of: 10.3390/biomedicines13030545
Publisher
MDPI
Language
en
Data types
JournalArticle
Keywords
orexinCOVID-19PASCinflammationcardiovascular systemautonomic nervous system
DFG-subjects
2.22-32 - Medizinische Physik, Biomedizinische Technik
Funding
Project Information:Gefördert durch den Open-Access-Publikationsfonds der UB Marburg.
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Attribution 4.0 International
URI
https://open.uni-marburg.de/handle/openumr/9780
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Ruhrländer, Jana; Syntila, Styliani; Schieffer, Elisabeth; Schieffer, Bernhard: The Orexin System and Its Impact on the Autonomic Nervous and Cardiometabolic System in Post-Acute Sequelae of COVID-19. In: Biomedicines 2025, 13, 545, Jg. (), .

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Attribution 4.0 International
Except where otherwised noted, this item's license is described as Attribution 4.0 International