Item type:Thesis, Open Access

Studie zur Häufigkeit und Art von Chromosomenanomalien unter frühen Spontanaborten ohne in vitro Wachstum - Retrospektive Untersuchung mittels Comparativer Genomhybridisierung (CGH)

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Date

2007-10-29

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Philipps-Universität Marburg
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Abstract

In the present study, we applied CGH to identify chromosome anomalies in 60 spontaneous abortions of the first trimester, that had failed to grow in culture. In 57 out of 60 cases CGH analyses were successful. The overall aneuploidy rate detected was 72%. Trisomy was the prodominant chromosome anomaly accounting for 68,3% of abnormal abortions, followed by triploidy (17,1%) and monosomy X (9,8%). An unbalanced structural rearrangement was found in one (2,4%) abortion. Most frequently involved in trisomies were chromosomes 16 (32,1%), 7 and 22 (10,7% each), 4, 13, 15, and 21 (7,2% each).

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Dates
Created: 2007Issued: 2007-10-29Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2007.0442
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
CGHSpontaneous abortionsChromosome aberration rateComparative genomic hybridisationCulture failuresCGHKulturversagenComparative Genomhybridisierung
DFG-subjects
SpontanabortChromosomenaberrationFehlgeburt
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2007.0442
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Pircher, Marion: Studie zur Häufigkeit und Art von Chromosomenanomalien unter frühen Spontanaborten ohne in vitro Wachstum - Retrospektive Untersuchung mittels Comparativer Genomhybridisierung (CGH). : Philipps-Universität Marburg 2007-10-29. DOI: https://doi.org/10.17192/z2007.0442.

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