Studie zur Häufigkeit und Art von Chromosomenanomalien unter frühen Spontanaborten ohne in vitro Wachstum - Retrospektive Untersuchung mittels Comparativer Genomhybridisierung (CGH)
Loading...
Files
Date
Authors
Publisher
Philipps-Universität Marburg
Abstract
In the present study, we applied CGH to identify chromosome anomalies in 60 spontaneous abortions of the first trimester, that had failed to grow in culture. In 57 out of 60 cases CGH analyses were successful. The overall aneuploidy rate detected was 72%. Trisomy was the prodominant chromosome anomaly accounting for 68,3% of abnormal abortions, followed by triploidy (17,1%) and monosomy X (9,8%). An unbalanced structural rearrangement was found in one (2,4%) abortion. Most frequently involved in trisomies were chromosomes 16 (32,1%), 7 and 22 (10,7% each), 4, 13, 15, and 21 (7,2% each).
Review
Metadata
License
This item has been published with the following license: In Copyright