Item type:Thesis, Open Access

Untersuchung der Plasmakonzentration von Diabetikern und Stoffwechselgesunden im Hinblick auf diabetogene Hormone unter besonderer Berücksichtigung von Resistin

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Date

2005-03-08

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Publisher

Philipps-Universität Marburg
DOI

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Abstract

Resistin is a recently discovered hormone that is exclusively expressed in adipose tissue. Its expression in rodents was reported to be elevated or suppressed in genetic and diet-induced obesity, respectively. Resistin treatment impaired glucose tolerance and insulin action. Immunoneutralization of resistin improved insulin sensitivity, while thiazolidinedione treatment reduced resistin expression. Therefore, resistin could play a critical role in the development of obesity and type 2 diabetes. In this study were determined resistin plasma levels in humans suffering from type 1 and type 2 diabetes and in healthy controls. Plasma levels of resistin in healthy controls were 38.78 ng/ml. They were not statistically different in individuals with a broad BMI range. Resistin plasma levels in type 2 diabetes were 38.7 ng/ml, and 39.4 ng/ml in type 1 diabetes. Thiazolidinedione treatment did not influence resistin plasma levels. We conclude from our data: 1. resistin can be detected in human plasma, 2. plasma resistin levels are not different in type 1 and type 2 diabetes.

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Dates
Created: 2004Issued: 2005-03-08Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2005.0027
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
DiabetesPlasma levelsResistin
DFG-subjects
PlasmakonzentrationResitinDiabetes
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2005.0027
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Heyn, Jens Michael: Untersuchung der Plasmakonzentration von Diabetikern und Stoffwechselgesunden im Hinblick auf diabetogene Hormone unter besonderer Berücksichtigung von Resistin. : Philipps-Universität Marburg 2005-03-08. DOI: https://doi.org/10.17192/z2005.0027.

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