Item type:Thesis, Open Access

HLA-Polymorphismus und Assoziationen mit der Dilatativen Kardiomyopathie, der Inflammatorischen Kardiomyopathie und der Myokarditis

Thumbnail Image

Files

dsemk.pdf (1.72 MB)

Date

2009-08-06

Authors

Publisher

Philipps-Universität Marburg
DOI

Supervisors

Abstract

We have undertaken this study to determine possible associations between myocarditis with and without cardiac dysfunction or idiopathic DCM and MHC class II, in particular HLA DQB1, alleles in a german population. Typing of HLA DQB1* allele was performed using a sequence-specific primer SSP-PCR technique in 22 unrelated patients with idiopathic DCM, 19 patients with myocarditis and normal left ventricular function, and 16 patients with myocarditis and impaired left ventricular function (i.e. inflammatory DCM). Controls comprised 44 patients without (inflammatory) cardiac disease and a population control. A significant association was found for presence of HLA DQB1*0303 with myocarditis without cardiac dysfunction in comparison to both control groups. In patients with inflammatory heart muscle disease (myocarditis or inflammatory DCM) a significant association was found with the presence of DQB1*03, DQB1*0301 and DQB1* 0303 as well as combination of both alleles. Allelic combination HLA DQB1*02-DQB1*03 is associated with inflammatory dilated cardiomyopathy. We were able to find associations between inflammatory heart muscle diseases and specific HLA-DQB1*alleles. In future and if confirmed by a larger prospective study HLA- DQB*1 alleles may be used as a diagnostic or prognostic marker.

Review

Metadata

Contributors
Supervisor:
Dates
Created: 2009Issued: 2009-08-06Updated: 2015-06-09
DOI
https://doi.org/10.17192/z2009.0505
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
CardiomyopathiesDCMMyocarditisHLA
DFG-subjects
HLAKongestive HerzmuskelkrankheitMyokarditis
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2009.0505
show more
Kreilinger Sabine (138927952): HLA-Polymorphismus und Assoziationen mit der Dilatativen Kardiomyopathie, der Inflammatorischen Kardiomyopathie und der Myokarditis. : Philipps-Universität Marburg 2009-08-06. DOI: https://doi.org/10.17192/z2009.0505.

License

item.page.license.under-copyright
This item has been published with the following license: In Copyright