Antibiotic Stewardship in der Intensivmedizin: Eine retrospektive Interventionsstudie
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Philipps-Universität Marburg
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Abstract
Shortly after the discovery of antibiotics the realization that bacteria can overcome the effects of antibiotic agents and develop resistance became present. Today, the phenomenon of antimicrobial resistance is one of the greatest threats to global health today. In 2016, the WHO published a global action plan to curb antimicrobial resistance and defined goals to counter this worldwide problem. One of them is to raise awareness and understanding of the threatening situation through education, effective communication, and training.
To strengthen the health system, Antibiotic Stewardship Programs have been introduced, among other infection prevention and control strategies. These are a set of coordinated actions to improve and optimize the use of antimicrobial drugs with the goal of improving patient health outcomes and reducing microbial resistance while reducing unnecessary costs. Meanwhile, the effectiveness of the ABS-Program is undisputed.
Due to the need to counteract the increasing development of resistance on our ward, daily ABS visits were introduced on our multidisciplinary intensive care unit. Although this tool is a useful part of the treatment decision, ABS measures cannot always be implemented permanently. In our case, daily ABS rounds were no longer possible due to the coronavirus pandemic. We now wanted to track whether the intensive exchange during the ABS intervention would have a sustainable effect in terms of antibiotic consumption, occurrence of multi-resistant pathogens, mortality, and length of stay. Therefore, we compared the first 6 months with daily participation of the ABS team with the following 6 months. In addition, a third group was included in the study, comprising all patients prior to the implementation of the ABS program. This period served as a control period.
Firstly, we were able to demonstrate that the ABS program was effective and led to a more appropriate, targeted and efficient use of antimicrobials. Consequently, as already shown in other studies, we found that antibiotic prescribing behavior improved and that length of stay and mortality were not negatively affected. We therefore saw the sustainability of a temporary intensive daily ABS intervention confirmed.
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Created: 2024Issued: 2024-10-30Updated: 2024-10-30
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Nosokomiale InfektionenAntibiotikaverbrauchLength of StayAntimicrobial ResistanceVerweildauerMortalitätAntibiotikaeinsatzMortalitätAntibiotic UsaRetrospective StudyIntensive Care UnitAntibiotic StewardshipMultidrug-resistant OrganismsInfection ControlMultiresistente ErregerHealthcare-associated InfectionsAntibiotic ConsumptionIntensivstationSepsisMortalityAntimikrobielle ResistenzInfektionskontrolleRetrospektive StudieSepsis
DFG-subjects
ResistenzMultidrug-ResistenzAntibiotikumSterblichkeitVerweildauerNachhaltigkeitVerbrauchIntensivstation
DDC-Numbers
610
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Dinu, Alex Constantin: Antibiotic Stewardship in der Intensivmedizin: Eine retrospektive Interventionsstudie. : Philipps-Universität Marburg 2024-10-30. DOI: https://doi.org/10.17192/z2024.0341.
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