Item type:Thesis, Open Access

Vergleich des 1 molaren Gadobutrol (Gadovist®) und des 0,5 molaren Gadobenat-Dimeglumin (MultiHance®) bei der kontrastmittelverstärkten Magnetresonanzangiographie der unteren Extremität

Thumbnail Image

Files

dma.pdf (700.72 KB)

Date

2011-08-10

Authors

Publisher

Philipps-Universität Marburg
DOI

Supervisors

Abstract

The purpose of this study was to compare the 0.5 molar MR-contrast agent Gadobenate Dimeglumine in half dose (0.05 mmol/kg bodyweight (BW)) to the 1 molar Gadobutrol in standard dose (0.1 mmol/kg BW) in run-off contrast-enhanced Magnetic Resonance Angiography (CE-MRA) of the lower extremities. 37 CE-MRAs at 1.5 Tesla from the infrarenal aorta to the calf arteries were retrospectively analysed with 0.1 mmol/kg BW Gadobutrol and 0.05 mmol/kg BW Gadobenate-Dimeglumine, respectively. Two independent blinded investigators analysed the occurrence of significant (> 70%) and non-significant (≤ 70%) stenosis as well as subjective image quality and venous overlay of CE-MRAs. A third investigator measured signal intensity, signal-to-noise-ratio (SNR) and contrast-to-noise-ratio (CNR) within all vessel segments from the infrarenal aorta to the popliteal artery. Interobserver agreement in detection of significant and non-significant stenosis was considerable with Gadobutrol (kappa = 0.547) as well as with Gadobenate Dimeglumine (kappa = 0.524). With regard to subjective image quality, no significant difference was shown for investigator 1 (p = 0.209). Investigator 2 noted a significantly better image quality with Gadobenate Dimeglumine (p < 0.05). Venous overlay occurred with similar frequency in both contrast agent groups (p = 0.132 and p= 0.06). As noted by both investigators, a high grade venous overlay in the area of the lower leg more often caused non-diagnostic image quality with Gadobutrol (in 1.4 und 2.6% of vessel segments) than with Gadobenate Dimeglumine (in 0.4 und 0.3 % of vessel sements). No significant difference between the contrast agents was noted with regard to signal intensity (p = 0. 28), SNR (p = 0.18) and CNR (p = 0.18). Using Gadobenate Dimeglumine, the gadolinium dose during CE-MRA of the lower extremities can be halfed without loss of image quality or signal intensity, SNR and CNR. Moreover, Gadobenate Dimeglumine should be favored over Gadobutrol due to the lower rate of non-diagnostic image quality.

Review

Metadata

Contributors
Supervisor:
Dates
Created: 2011Issued: 2011-08-10Updated: 2011-08-11
DOI
https://doi.org/10.17192/z2011.0461
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Gadobutrolrun-off MRAGadobenate DimeglumineGadobenat-DimegluminGadobutrollower extremities
DFG-subjects
KontrastmittelMagnetresonanzangiographieNichtionisches KontrastmittelPeriphere arterielle Verschlusskrankheit
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2011.0461
show more
Achenbach, Marina: Vergleich des 1 molaren Gadobutrol (Gadovist®) und des 0,5 molaren Gadobenat-Dimeglumin (MultiHance®) bei der kontrastmittelverstärkten Magnetresonanzangiographie der unteren Extremität. : Philipps-Universität Marburg 2011-08-10. DOI: https://doi.org/10.17192/z2011.0461.

License

item.page.license.under-copyright
This item has been published with the following license: In Copyright