Item type:Doctoral Thesis, Open Access

Untersuchungen zur ligandenvermittelten Regulation der Melanocortin-Rezeptor-Aktivität

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Date

2009-03-25

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Philipps-Universität Marburg
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Abstract

Melanocortin-Receptors are playing an important role in the maintenance of energy homeostasis. Alpha-MSH a Melanocortin-Receptor agonist induces arrestin-mediated Endocytosis of the Melanocortin-3-Receptor (MC3R). Similar effects have already been shown for the Melanocortin-4-Receptor (MC4R). Agouti-related-Protein the natural inverse agonist of MCR also induces arrestin-mediated endocytosis of MC3R and MC4R. The MC4R mutant D90N which has lost the ability of G-Protein-Activation recruits beta-arrestin after agonist-stimulation but does not show endocytosis.

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Dates
Created: 2009Issued: 2009-03-25Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2009.0050
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
AgoutiAgRPD90NGPCRArrestinMCR
DFG-subjects
EndocytoseMelanotropin
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2009.0050
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Wolff, Katharina (112068103): Untersuchungen zur ligandenvermittelten Regulation der Melanocortin-Rezeptor-Aktivität. : Philipps-Universität Marburg 2009-03-25. DOI: https://doi.org/10.17192/z2009.0050.

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