Diffusion Tensor Imaging (DTI) bei Patienten mit REM Sleep Behavior Disorder (RBD)
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Philipps-Universität Marburg
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Abstract
Introduction
Idiopathic REM sleep behavior disorder (iRBD) - a parasomnia characterized by dream enactments – is a risk factor for the development of Parkinson's disease (PD) and other alpha-synucleinopathies. The pathophysiology of iRBD is likely due to a dysfunction of brainstem nuclei that regulate REM sleep.
Material and Methods
Diffusion tensor imaging (DTI) of the brain is a method for studying the microstructural brain tissue integrity in vivo. We investigated whether DTI detects microstructural abnormalities in brains of patients with iRBD - compared with age-matched controls - as a potential in vivo indicator for changes related to “preclinical (premotor)” PD neuropathology. Patients with iRBD (n=12) and age-matched healthy controls (n=12) were studied using a routine 1.5T MRI scanner. Whole-head DTI scans (measuring fractional anisotropy (FA), axial diffusivity (AD), a potential marker of neuronal loss and radial diffusivity (RD), a potential marker of myelin pathology, were analyzed without a priori hypothesis using tract-based spatial statistics (TBSS), a novel technique minimizing edge-related artifacts and alignment difficulties.
Results
Using group analysis, we found significant microstructural brain tissue changes (p < 0.0001) in the white matter of the brainstem (AD), the olfactory region (FA), the left temporal lobe (RD), the fornix (RD), the internal capsule (FA), the corona radiata (AD), the right visual stream (RD) and the right substantia nigra (AD) of the iRBD patients.
Discussion
These microstructural abnormalities were identified in regions known to either be involved in REM-sleep regulation (brainstem) and/or to exhibit neurodegenerative pathology in iRBD and/or early PD. The study suggests that iRBD-related microstructural abnormalities can be detected in vivo with DTI, a widely available MRI technique.
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Dates
Created: 2013Issued: 2013-12-18Updated: 2013-12-18
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
RBDDTIDTIMRTMRIRBD
DFG-subjects
Diffusionsgewichtete MagnetresonanztomografieNMR-Tomographie
DDC-Numbers
610
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Belke, Marcus (1045774723): Diffusion Tensor Imaging (DTI) bei Patienten mit REM Sleep Behavior Disorder (RBD). : Philipps-Universität Marburg 2013-12-18. DOI: https://doi.org/10.17192/z2013.0730.
License
This item has been published with the following license: In Copyright