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Philipps-Universität Marburg
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This dissertation describes the total synthesis of two natural products cladoniamide G and cladoniamide F which belong to the group of indenotryptolines that is closely related to the natural product class of indolocarbazoles. Key steps of the synthesis were the addition of an indole to a mesoxalic ester amide, a Suzuki cross-coupling of two indoles and an intramolecular lactam formation. Additionally, a method for the enantioselective addtion of indoles to mesoxalic ester amides was developed.
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This item has been published with the following license: In Copyright