Die Lebensqualität von Patienten mit chronisch inflammatorischer demyelinisierender Polyradikuloneuropathie in Deutschland
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Philipps-Universität Marburg
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Abstract
The aim of this clinical, multicenter cross-sectional study was to examine CIDP patients for a decrease in their quality of life as the severity of the disease increases. It should be emphasized that their quality of life depends on the severity of CIDP disease and not on comorbidities. Therefore, this study was carried out with a cohort of n=108 CIDP patients whose average age was 62.5 years and of whom n=67 subjects had typical CIDP and n=41 had a CIDP variant. Using doctor and patient questionnaires as well as a clinical neurological examination, we determined the clinical status (INCAT, MRC, ISS), the comorbidities, the original Charlson comorbidity index (CCI), the health-related quality of life (EQ-5D, WHOQOL-BREF), and the depressive Symptoms (BDI-II) and cognitive status (MMST). We then assigned the CIDP patients a severity category and analyzed their reported quality of life. As a result, the increase in severity category correlated with worsening quality of life. The situation was different for the comorbidities; for this, the severity categories of the CCI were examined for a statistical connection with the CIDP severity and quality of life. There were no correlations and no meaningful mean distributions. This means that the quality of life of our study cohort seemed to deteriorate due to the CIDP-related physical limitations and not due to any comorbidities. In comparison, it is worse than that of the general population and patients with multiple sclerosis, myasthenia or stroke, but better than that of patients with Alzheimer's dementia or amyotrophic lateral sclerosis. The women in this study were more severely affected in terms of clinical status, quality of life and depressive symptoms. Most CIDP patients were in the mild or mild severity category, and they also showed more severe sensory than motor functional impairments and an emphasis on the lower extremities. The connections between the ISS with BDI-II and WQ-Psychisch suggest a stronger influence of the sensitive functional limitations on the depressive symptoms and psychology of our test subjects. The comorbidities in this study included, among others, arterial hypertension, musculoskeletal diseases, cardiac diseases, pulmonological diseases, type 2 diabetes mellitus, cancer, bladder or kidney diseases and thyroid diseases. Furthermore, unemployment due to CIDP disease had a negative effect on INCAT, WHOQOL-BREF and EQ-5D-VAS. Our results highlight existing evidence that early detection and treatment of the severity of CIDP patients could contribute to improving their quality of life.
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Created: 2024Issued: 2024-12-09Updated: 2024-12-09
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
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DoctoralThesis
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CIDP
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610
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Schmit, Andreas: Die Lebensqualität von Patienten mit chronisch inflammatorischer demyelinisierender Polyradikuloneuropathie in Deutschland. : Philipps-Universität Marburg 2024-12-09. DOI: https://doi.org/10.17192/z2024.0373.
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This item has been published with the following license: In Copyright