Item type:Thesis, Open Access

Neue Zielgene des Transkriptionsfaktors E2F-1 und die transkriptionelle Regulation des MYCN Onkogens im humanen Neuroblastom

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Date

2008-01-25

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Philipps-Universität Marburg
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Abstract

The neuroblastoma is the most common solid pediatric tumor outside the central nervous system. The amplification and expression of the oncogene MYCN in neuroblastoma is associated with a very poor prognosis. The regulation of the MYCN expression is controlled by E2F transcription factors, which can in turn be activated by myc proteins. In addition to previously known E2F-1 activated genes it could be shown that the BMI-1 gene is also regulated by E2F-1. The Bmi1 protein is a member of the polycomb group of proteins that are known to have oncogenic functions. In a second project MYCN promotor-specific proteins could be enriched by means of affinity chromatography. This provides the basis for future characterisation of possible MYCN activating transcription factors.

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Dates
Created: 2007Issued: 2008-01-25Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2008.0013
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
NeuroblastomaBMI1E2F-1Mycn
DFG-subjects
BMI1E2F-1NeruoblastomMYCN
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2008.0013
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Kramps, Christoph Matthias: Neue Zielgene des Transkriptionsfaktors E2F-1 und die transkriptionelle Regulation des MYCN Onkogens im humanen Neuroblastom. : Philipps-Universität Marburg 2008-01-25. DOI: https://doi.org/10.17192/z2008.0013.

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