Item type:Doctoral Thesis, Open Access

Transduktion und Zellzyklusregulation durch das rekombinante Tat-p27(KIP1)-Fusionsprotein in Neuroblastomzellen

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Date

2004-12-30

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Philipps-Universität Marburg
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Abstract

Neuroblastoma is one of the frequent tumor of childhood. The tumorsuppresor, p27(KIP1), is a prognostic factor and correlates with a favourable prognosis of neuroblastoma disease. Tat-fusion-protein is a newly found tool for proteintransduction and is an alternative to conventional gentherapy. In the present work I create the Tat-p27(KIP1)-fusion protein and transduced it into neuroblastoma cells. The consequent results in cell cycle situation were investigated to understand more about the prognostic meanings of p27(KIP1) in neuroblastomas.

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Dates
Created: 2003Issued: 2004-12-30Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2004.0662
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Cell cyclep27Tat-FusionsproteinNeuroblastomaTatNeuroblastomZellzyklusp27
DFG-subjects
GentherapieNeuroblastomZellzyklus
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2004.0662
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Shin, In-Hee: Transduktion und Zellzyklusregulation durch das rekombinante Tat-p27(KIP1)-Fusionsprotein in Neuroblastomzellen. : Philipps-Universität Marburg 2004-12-30. DOI: https://doi.org/10.17192/z2004.0662.

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