Item type:Doctoral Thesis, Open Access

Pharmakogenetik der Wachstumshormonsubstitution bei Hypophysenvorderlappeninsuffizienz: Der Collagen-I-alpha-1-SP1-Polymorphismus

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Date

2009-01-12

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Publisher

Philipps-Universität Marburg
DOI

Supervisors

Abstract

The COLIA1 SP1-Polymorphism is related to the dose of individually required, subcutaneous injected hGH in GH-deficient adults, probably because of an alteration of the subcutaneous collagen type I structure, content and/or biological/biomechanical properties. GG honozytotism, which is related to a more stable bone structure and decreased fracture risk, may impact skin resistance to subcutaneous injected protein-based drugs, as shown for hGH in this study.

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Dates
Created: 2008Issued: 2009-01-12Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2008.0983
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
COLIa1 SP1-polymorphism
DFG-subjects
COLIa1-SP1-PolymorphismusGH-Mangel
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2008.0983
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Horn, Marlitt: Pharmakogenetik der Wachstumshormonsubstitution bei Hypophysenvorderlappeninsuffizienz: Der Collagen-I-alpha-1-SP1-Polymorphismus. : Philipps-Universität Marburg 2009-01-12. DOI: https://doi.org/10.17192/z2008.0983.

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