Item type:Thesis, Open Access

Expression unf Funktion von Makrophagen Migrations-Inhibitions-Faktor in humanen Glioblastomzelllinien

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Date

2005-07-28

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Philipps-Universität Marburg
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Abstract

The cytokine macrophage migration inhibitory factor (MIF) has been identified as a factor in the developement and progression of cancer, besides its many functions in the immune system. This thesis analysis the expression and function of MIF in human glioblastoma cells. MIF is upregulated and secreted in response to angiogenetic stimuli eg. hypoxia and glucose withdrawl in the tumour cell culture. Targeting MIF by antisense strategy and blockade by antibodies results in a decreased proliferation and in reintroduction of conatct inhibition in the glioblastoma cells.

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Dates
Created: 2005Issued: 2005-07-28Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2005.0352
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
GlioblastomImmunologieAngiogeneseMIFTumorbiologieImmunologyAngiogenesisMIFGlioblastoma
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2005.0352
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Schrader, Jörg (130177792): Expression unf Funktion von Makrophagen Migrations-Inhibitions-Faktor in humanen Glioblastomzelllinien. : Philipps-Universität Marburg 2005-07-28. DOI: https://doi.org/10.17192/z2005.0352.

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