Item type:Thesis, Open Access

Untersuchungen zur Bedeutung des distalen Kolons für die Funktionsfähigkeit der enteroinsulären Achse

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Date

2007-04-12

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Philipps-Universität Marburg
DOI

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Abstract

This study addresses the question whether the insulinotropic gut hormone, glucagon-like peptide-1 (GLP-1), is released from the lower large bowel upon oral or rectal glucose uptake. Methods: It was evaluated whether rectum or sigmoid colon resection alters glucose homeostasis or the plasma levels of the insulinotropic gut hormone, gastric inhibitory polypeptide (GIP), or GLP-1. eight men and 3 women (age 63 ± 8 years, BMI 25.4 ± 4.0 kg/m2) with normal preoperative fasting glucose values were treated before and after resection of large bowel segments. Fasting oral glucose tolerance (OGT, 75 g glucose/300 ml) tests were performed both before and 10 days postoperatively. Another approach aimed to clarify whether luminal glucose stimulation in the rectum/sigmoid colon increases GLP-1 plasma levels.

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Dates
Created: 2007Issued: 2007-04-12Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2007.0197
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Glukagon like peptide
DFG-subjects
Glukagon like peptide
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2007.0197
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Samadi Ahadi, Nader: Untersuchungen zur Bedeutung des distalen Kolons für die Funktionsfähigkeit der enteroinsulären Achse. : Philipps-Universität Marburg 2007-04-12. DOI: https://doi.org/10.17192/z2007.0197.

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This item has been published with the following license: In Copyright