End stage renal disease, in particular renal fibrosis as pathological result, forces patients into a hard therapy and increases mortality rate. The following in vivo studies are about calcium-activated potassium channels, in particular KCa3.1, and their crucial importance in progressing renal fibrosis. A pharmacological blockade of the channel could be an important starting point for the future.
Sautter, Julia: Die Rolle Kalzium-abhängiger Kaliumkanäle bei UUO-induzierter Nierenfibrose. : Philipps-Universität Marburg 2010-10-13. DOI: https://doi.org/10.17192/z2010.0563.
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