Item type:Thesis, Open Access

Bestimmung des immunologischen Therapieeffekts und der Sicherheit der Vakzinierung mit dem anti-idiotypischen murinen monoklonalen Antikörper mAb ACA125 (Anti-Id OC125) bei Patientinnen mit fortgeschrittenem Ovarialkarzinom

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Date

2008-06-24

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Philipps-Universität Marburg
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Abstract

PURPOSE: A Phase I/IIb multicenter study was conducted to evaluate the safety and immunogenicity of the anti-idiotypic antibody vaccine ACA125 that functionally imitates the tumor antigen CA125 in 119 patients with advanced ovarian carcinoma. A preliminary report on the initial 42 patients demonstrated safety and immunogenicity. EXPERIMENTAL DESIGN: Using the complete intention-to-treat population (n = 119) who received a mean of 9.7 ACA125 applications, survival was analyzed with respect to immunological responses. RESULTS: In 81 patients (68.1%), a specific anti-anti-idiotypic antibody (Ab3) response could be induced. Additionally, the development of CA125-specific antibodies (Ab1´) and antibody-dependent cell-mediated cytotoxicity of CA125-positive tumor cells was observed in 50.4% and 26.9% of patients, respectively. The median survival of all patients was 19.4 months (range, 0.5-56.1 months). Ab3-positive patients showed a significantly longer survival (median, 23.4 months; P < 0.0001) as compared with Ab3-negative patients (median, 4.9 months). A positive Ab3 response remained associated with longer survival when controlling for other prognostic factors including FIGO (International Federation of Gynecologists and Obstetricians) stage, response to and type of first-line chemotherapy, number of previous treatments, or concomitant antitumor therapy. With regard to safety, repeated vaccination was well tolerated. No serious adverse events related to the application of ACA125 occurred. CONCLUSIONS: Although the uncontrolled design of this study prevents definitive conclusions with respect to subgroups, the data support a relationship between Ab3 response and survival time. Thus, the need for further randomized, controlled clinical trials to establish efficacy of the vaccine ACA125 seems to be indicated.

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Dates
Created: 2008Issued: 2008-06-24Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2008.0428
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
CA125VakzinationVaccinationAntiidiotypeCA125AntibodyOvarialkarzinomAntiidiotypAntikörperOvarian cancer
DFG-subjects
AntiidiotypVakzinationAntikörperCA125Ovarialkarzinom
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2008.0428
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Giffels, Patrick (135756995): Bestimmung des immunologischen Therapieeffekts und der Sicherheit der Vakzinierung mit dem anti-idiotypischen murinen monoklonalen Antikörper mAb ACA125 (Anti-Id OC125) bei Patientinnen mit fortgeschrittenem Ovarialkarzinom. : Philipps-Universität Marburg 2008-06-24. DOI: https://doi.org/10.17192/z2008.0428.

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