Die Peptide CGRP, Adrenomedullin und PTHrP bewirken eine Dilatation der Koronargefäße durch Aktivierung von KATP-Kanälen.
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Philipps-Universität Marburg
Abstract
CGRP, adrenomedulline and PTHrP have been known for being vasoactive substances since the middle 80s. Up to now, research about their vasoactive potencial was only performed in cells and non-isolated organs. The isolated perfused mouse heart can show us an isolated view of the whole organ. Besides that, we know that there is a great homology of the mice genome to the human genome. We could show for the first time in the isolated perfused mouse heart that
CGRP is a strong vasodilatating peptide
adrenomedulline is a strong vasodilatating peptide
PTHrP is a strong vasodilatating peptide
CGRP and Adrenomedullin show almost identically effects used in the same concentration
the KATP-channels play an extremely important role in vasodilatating effects of the peptides CGRP, adrenomedulline and PTHrP
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This item has been published with the following license: In Copyright