Item type:Thesis, Open Access

Die Peptide CGRP, Adrenomedullin und PTHrP bewirken eine Dilatation der Koronargefäße durch Aktivierung von KATP-Kanälen.

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Date

2003-06-20

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Publisher

Philipps-Universität Marburg
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Abstract

CGRP, adrenomedulline and PTHrP have been known for being vasoactive substances since the middle 80s. Up to now, research about their vasoactive potencial was only performed in cells and non-isolated organs. The isolated perfused mouse heart can show us an isolated view of the whole organ. Besides that, we know that there is a great homology of the mice genome to the human genome. We could show for the first time in the isolated perfused mouse heart that CGRP is a strong vasodilatating peptide adrenomedulline is a strong vasodilatating peptide PTHrP is a strong vasodilatating peptide CGRP and Adrenomedullin show almost identically effects used in the same concentration the KATP-channels play an extremely important role in vasodilatating effects of the peptides CGRP, adrenomedulline and PTHrP

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Dates
Created: 2002Issued: 2003-06-20Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2003.0375
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
KATPion channelCGRPpotassiumadrenomedulline
DFG-subjects
LangendoCalcitonin gene-related peptideIonenkanalVasodilatationParathyroid hormone-like peptideKoronararterieAdrenomedullinKalium
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2003.0375
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Gerhardus, Jan: Die Peptide CGRP, Adrenomedullin und PTHrP bewirken eine Dilatation der Koronargefäße durch Aktivierung von KATP-Kanälen.. : Philipps-Universität Marburg 2003-06-20. DOI: https://doi.org/10.17192/z2003.0375.

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