Einfluss unterschiedlicher Konservierungsmethoden auf die mechanische in vitro Stabilität von Knochen am Beispiel porciner Metatarsalia
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Philipps-Universität Marburg
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Abstract
For the establishment of new orthopedic or trauma-surgical implants there are multiple test methods on in vitro specimens. Commonly used specimens for biomechanical testing are fresh, fresh frozen and formalin embalmed bones. To what extent the conservation or embalming method influences the mechanical properties, is insufficiently investigated.
The aim of this study was to investigate the influence of different conservation and embalming methods of bones on mechanical properties under standardized conditions.
Fresh porcine metatarsals were divided into seven groups of conservation and embalming methods: fresh bones, fresh frozen (-18°C), in vacuum cooled (4°C), embalmed with formalin, embalmed with Thiel-Fixation and embalmed with glycerol. Before and after conservation/embalming the specimens underwent a bone density measurement with Dual X-Ray Absorptiometry (DXA).
For the mechanical testing and fracture-establishment a 3-point-bending-model was used.
To examine the influence of conservation/embalming on an osteosynthesis, the fractured specimens were treated with a plate osteosynthesis (DCP System, Synthes® Umkirch Germany).
Considering the results on fracture-establishment, one could see a more consistent fracture-pattern among the chemical embalming methods, on the contrary to fresh or physical preserved specimens. Regarding the maximum load and load to failure there was no statistic significant difference. However, taking the compression deformation in
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the event of fracture into consideration, there is a statistic significant lowering of the formalin and glycerol embalmed specimens, compared to fresh specimens. Comparable results were found at deformation at maximum load. After osteosynthesis, there is also significantly less compression deformation after chemical embalming compared to fresh specimens.
As the results show, the physical preservation methods tested have no influence on the mechanical stability of bones. In the case of chemical embalming, on the other hand, this statement only applies to a limited extent, so that bones preserved in this way should only be used for selected questions.
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Created: 2023Issued: 2023-12-04Updated: 2023-12-05
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
thielbiomechanicsboneporcineBiomechanik,conservationKonservierungsmethodenfixationembalmingformalinosteosynthesisFixierungsmethoden
DFG-subjects
PorcineFormalinAlkohol-GlycerinKonservierungThielFixierungKnochenMetatarsaliaBiomechanikFrech-Frozen
DDC-Numbers
610
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Dos Santos, Vanessa: Einfluss unterschiedlicher Konservierungsmethoden auf die mechanische in vitro Stabilität von Knochen am Beispiel porciner Metatarsalia. : Philipps-Universität Marburg 2023-12-04. DOI: https://doi.org/10.17192/z2023.0608.
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This item has been published with the following license: In Copyright