Item type:Thesis, Open Access

Telomeraseaktivität beim Neuroblastom: prognostische Bedeutung in Abhängigkeit von MYCN-Amplifikation, Stadium, Alter bei Diagnose, Histologie und Geschlecht

Thumbnail Image

Files

dss.pdf (302.41 KB)

Date

2008-02-20

relationships.isAuthorOf

Publisher

Philipps-Universität Marburg
DOI

item.page.supervisor-of-thesis

Abstract

Neuroblastoma as the second most common solid tumour in childhood shows an extraordinary biological heterogeneity ranging from spontaneous regression of metastatic tumours to rapid progression despite multimodal therapy. To determine the optimal treatment strategy for each individual patient with neuroblastoma, genetic factors play a decisive role in risk stratification. For two decades, amplification of the MYCN oncogene has been established as a clinical marker for unfavourable prognostic outcome. Recent reports suggest an important role also for telomerase in neuroblastomas. Telomerase is an enzyme that helps the cell to overcome its limited ability to proliferate. Since telomerase activity is absent in most non-neoplastic tissues and somatic cells but can be detected in almost all malignant tumours, it has potential as an diagnostic marker for malignancy. In this study we examined the prognostic importance of telomerase activity in neuroblastoma. In 304 tumours telomerase acitvity levels were determined using the telomeric repeat amplification protocol (TRAP). Genomic status of MYCN was quantified by PCR. Univariate and multivariate analyses were performed for telomerase activity, amplification status of MYCN, the variables tumour stage, age at first biopsy, histopathological grading and gender. This study could demonstrate in a large series of neuroblastomas that elevated levels of telomerase activity are associated with poor prognosis independently of known clinical parameters as tumour stage, age at diagnosis, histopathological grading and amplification of the oncogene MYCN. In addition, both amplification of MYCN and tumour stage 4 were affirmed as independent prognostic factors in neuroblastoma.

Review

Metadata

Contributors
Supervisor:
Dates
Created: 2008Issued: 2008-02-20Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2008.0018
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Telomeraseaktivitättelomerase activityNeuroblastoma
DFG-subjects
NeuroblastomTelomerase
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2008.0018
show more
Schiel, Sibylle (133897583): Telomeraseaktivität beim Neuroblastom: prognostische Bedeutung in Abhängigkeit von MYCN-Amplifikation, Stadium, Alter bei Diagnose, Histologie und Geschlecht. : Philipps-Universität Marburg 2008-02-20. DOI: https://doi.org/10.17192/z2008.0018.

License

item.page.license.under-copyright
This item has been published with the following license: In Copyright