Functional description of the BCR/JAK2 fusion gene, which has been described in a patient suffering from chronic myeloid leukaemia in 2005. The T(translocation)(9;22)(p24;q11.2)leads to the formation of a fusion gene which incorporates critical regions of the breakpoint cluster region- as well as the janus kinase 2 gene. A combination of the coiled-coil dimerization domain of BCR and the JH1 tyrosine kinase domain of JAK2 generates a tumouringenic fusion protein capable of inducing Il-3 independent proliferation in an IL-3 dependent cell line.
Marbach, Felix: Functional Characterization of the BCR/JAK2 Fusion Gene in a Murine Pro B Cell Line. : Philipps-Universität Marburg 2015-12-16. DOI: https://doi.org/10.17192/z2015.0626.
License
This item has been published with the following license: In Copyright
