Item type:Thesis, Open Access

Prognosefaktoren beim nichtkleinzelligen Bronchialkarzinom - Inzidenz von p53, bcl-2, HER-2, HSP27, HSP60 und HSP70 in nichtkleinzelligen Bronchialkarzinomen des Stadiums IIIA

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Date

2003-11-13

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Philipps-Universität Marburg
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Abstract

Lung cancer is one of leading causes of cancer death in the world. Patients with similar stage of disease show differences in probabilities of survival. This illustrates the need to identify new prognostic factors that may help to optimize therapeutic efforts for each individual patient. The aim of this study was to document the incidence of p53, bcl-2, HER-2, HSP27, HSP60 and HSP70 in stage IIIA non-small cell lung carcinomas. We investigated 34 non-small lung cancers for prognostic factors overexpression by immunohistochemistry. Of the 34 NSCLC tissues studied, the presence of p53 was demonstrated in 16 of 34 (47,05 %), HER-2 in 3 of 30 (10 %), HSP27 in 29 of 34 (85,29 %), HSP60 in 21 of 34 (61,76 %) and HSP70 in 8 of 34 tissues (23,52 %). Noteworthy there was no clear overexpression of bcl-2 in any of the investigated tissues. Statistical comparison revealed no significant differences between protein overexpression and the patients clinical characteristics.

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Dates
Created: 2003Issued: 2003-11-13Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2003.0697
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Prognosefaktorenp53HitzeschockproteinHSP70HSP60HER-2HSP27bcl-2 ,p53Stadium IIIA
DFG-subjects
Nicht-kleinzelliges BronchialkarzinomLungenkrebs
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2003.0697
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Schwindel, Uwe (128601167): Prognosefaktoren beim nichtkleinzelligen Bronchialkarzinom - Inzidenz von p53, bcl-2, HER-2, HSP27, HSP60 und HSP70 in nichtkleinzelligen Bronchialkarzinomen des Stadiums IIIA. : Philipps-Universität Marburg 2003-11-13. DOI: https://doi.org/10.17192/z2003.0697.

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This item has been published with the following license: In Copyright