Item type:Thesis, Open Access

Expression, Regulation und subzelluäre Lokalisation von Tight Junction-Komponenten in Metastasierungsmodellen humaner duktaler Pankreaskarzinomzellen

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Date

2008-06-24

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Philipps-Universität Marburg
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Abstract

Prognosis of pancreatic ductal carinoma is very poor due to most late diagnosis of an inoperable or metastasized tumor. Therefore, understanding of the process of metastasis is highly relevant in treatmant of pancreatic ductal carinoma. The Tight Junction proteins (claudins, occludin), tight junction associated Proteins (ZO-1, ZO-2) and adherens junction proteins (E-Cadherin) may be involved in this process and, hence, were subject to further investigations concerning their expression, regulation and localization in models for metastasis of human ductal pancreatic carcinoma cells. Expression of the Tight junction components was not found clearly assoziated to the grade of metastasis in pancreatic ductal carcinoma cells, however, their lokation was regulated by activation of the MAPK-cascade. In neuroendocrine pancreatic carcinoma cell lines also DNA hypermethylation seems to influence the expression of single members of the claudine family.

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Dates
Created: 2008Issued: 2008-06-24Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2008.0418
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Pancreatic ductal carcinomaTight Junction
DFG-subjects
Tight junctionMetastaseBauchspeicheldrüsenkrebs
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2008.0418
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Aurbek, Nadine (134208013): Expression, Regulation und subzelluäre Lokalisation von Tight Junction-Komponenten in Metastasierungsmodellen humaner duktaler Pankreaskarzinomzellen. : Philipps-Universität Marburg 2008-06-24. DOI: https://doi.org/10.17192/z2008.0418.

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