Item type:Thesis, Open Access

Untersuchung zur Korrelation von HLA-DR-Expression, Procalcitonin und Interleukin 6 mit dem Krankheitsverlauf sowie ihrer Eignung zur Risikostratifizierung bei Patienten mit Sepsis

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Date

2011-08-22

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Publisher

Philipps-Universität Marburg
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Abstract

This study analysed at 111 patients with sepsis the relation of the temporal kinetics of interleukin 6, procalcitonin and HLA-DR expression on monocytes with the disease and their ability for early risk stratification. It was found in the developed logistic regression models a statistical trend, that after 48 hours the HLA-DR expression on monocytes can give evidence of the further clinical development of the patient and thus potentially of the effectiveness of the current therapy of sepsis (p = 0.0923). Certainly there are further multicenter studies with larger study populations necessary to detect a statistically significant and positive effect on the outcome. For PCT and IL-6 there was neither a statistical significance nor a statistical trend found in this regard. In addition, in the created Cox regression models the already by other research groups proven suitability of the APACHE II score for early risk stratification was confirmed (p = 0.0098). For IL-6 as well such an association with the risk of death could be shown (p = 0.0148). For PCT and HLA-DR no association with the risk of death was detectable.

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Dates
Created: 2011Issued: 2011-08-22Updated: 2011-09-13
DOI
https://doi.org/10.17192/z2011.0548
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
SepsisHLA-DRProcalcitoninInterleukin 6
DFG-subjects
SepsisInterleukin 6ProcalcitoninHLA-DR
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2011.0548
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Schumann, Florian: Untersuchung zur Korrelation von HLA-DR-Expression, Procalcitonin und Interleukin 6 mit dem Krankheitsverlauf sowie ihrer Eignung zur Risikostratifizierung bei Patienten mit Sepsis. : Philipps-Universität Marburg 2011-08-22. DOI: https://doi.org/10.17192/z2011.0548.

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