Item type:Thesis, Open Access

Biodegradable Paclitaxel-loaded Nanoparticles and Stent Coatings as Local Delivery Systems for the Prevention of Restenosis

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Date

2004-03-24

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Philipps-Universität Marburg
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Abstract

Despite improved technologies restenosis remains the main problem of catheter-based interventions after a percutaneous transluminal angioplasty in artery disease. Local and sustained application of antiproliferative agents is a promising approach to solve the problem of intimal hyperplasia. In recent years, two different concepts for local drug delivery have attained increased importance: On the one hand, colloidal drug carriers, which can be infused directly into the vessel wall during the angioplasty procedure using special delivery catheters and on the other hand, the development of drug eluting stents. Biocompatible, biodegradable polymers are one of the most important instruments used to control the release of pharmacological active substances. A new type of branched, biodegradable polyesters, poly(vinyl alcohol)-graft-poly(lactide-co-glycolide) (PVA-g-PLGA), possesses very interesting features for the local and sustained release of paclitaxel. Therefore, the objective of this work was to investigate these polymers with regard to the preparation of paclitaxel loaded nanoparticles and stent coatings, and to evaluate their applicability as drug carriers to prevent intimal hyperplasia.

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Dates
Created: 2004Issued: 2004-03-24Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2004.0098
Faculty
Fachbereich Pharmazie
Publisher
Philipps-Universität Marburg
Language
eng
Data types
DoctoralThesis
Keywords
Paclitaxel , Biodegradable polymersRestenosisStentbeschichtungenbioabbaubare PolymereNanoparticles, Stent coatingsPaclitaxel
DFG-subjects
Biologisch abbaubarer KunststoffRestenoseTaxol , KoronarendoprotheseNanopartikel
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2004.0098
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Westedt, Ulrich (128939869): Biodegradable Paclitaxel-loaded Nanoparticles and Stent Coatings as Local Delivery Systems for the Prevention of Restenosis. : Philipps-Universität Marburg 2004-03-24. DOI: https://doi.org/10.17192/z2004.0098.

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