Item type:Thesis, Open Access

Untersuchung der Rolle von Neurotrophinen in der Zellphysiologie von Atemwegsepithelzellen am Beispiel der murinen Lungenepithelzellinie LA-4

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Date

2011-02-18

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Philipps-Universität Marburg
DOI

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Abstract

In allergic asthma the development of allergic inflammation and neuronal hyperresponsiveness are functionally associated. One group of mediators of this neuroimmune interaction is the neurotrophin family, members of which are intensively produced in the allergic lung. In addition to immune cells both smooth muscle cells and fibroblasts are capable of producing members of the neurotrophin family. This study presents the lung epithelial cells as an additional source for neurotrophins. Interestingly, epithelial neurotrophin secretion is shown to be increased by both the proinflammatory cytokines, TNFa and IL-1b and the Th2-associated cytokines (IL-4, IL-5, IL-13). These data underline the contribution of the lung epithelium to the complex interaction between immune cells, the nervous system and structural cells of the lung underlying the pathomechanism of asthma. In due consideration of the epithelial expression of the neurotrophin receptors, trkA and trkb, during the stage of proliferation, the role of NGF and BDNF as autocrine growth factors becomes clear.

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Dates
Created: 2011Issued: 2011-02-18Updated: 2011-08-08
DOI
https://doi.org/10.17192/z2011.0029
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
AsthmaNerve growth factorLungenepithelzellenAirway epithelial cellsAirway inflammationNeurotrophineBrain-derived neurotrophic factor
DFG-subjects
Neurotropher FaktorEpithelBronchialasthma
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2011.0029
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Pirayesh Islamian, Ariyan (143652451): Untersuchung der Rolle von Neurotrophinen in der Zellphysiologie von Atemwegsepithelzellen am Beispiel der murinen Lungenepithelzellinie LA-4. : Philipps-Universität Marburg 2011-02-18. DOI: https://doi.org/10.17192/z2011.0029.

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This item has been published with the following license: In Copyright