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Philipps-Universität Marburg
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Abstract
NOD1 and NOD2 are a subset of Pattern Recognition Receptors (PRR), which can
recognize pathogens based on their pathogen-associated molecular patterns (PAMPs)
and thus regulate the innate immune response. Activation of NOD signaling leads to a
complex inflammatory process, which is considered as the basis for the development of
atherosclerosis and other diseases.
Our group has already observed the influence of NOD1 and NOD2 on inflammation and
atherogenesis. Based on these findings, this work investigated the expression of
macrophages of wild-type mice after NOD stimulation with respect to cytokines,
interleukins and other inflammatory mediators. Additionally, the influence of NOD
stimulation on uptake/transport of cholesterol and foam cell formation were analyzed.
This project shows that NOD stimulation of wild-type macrophages has a strong
influence on the inflammatory process, as well as on the expression of scavenger
receptors and efflux transporters. NOD stimulation led to an increased expression of the
cytokines and interleukins. In addition, it was found that NOD stimulation caused an
increased expression of the scavenger receptors such as SRA-1 and LOX-1. Also, a
delayed induced ABCA-1 expression could be detected.
In the second part of this work, two different methods were used to demonstrate that a
systemic NOD1 and NOD2 deficiency leads to a reduction in foam cell formation.
Furthermore, the influence of intravenous NOD activation on bone marrow cells, plasma
and PBMCs was investigated.
In summary, this research provides new insights into the role of NOD signaling within the
macrophage with regard to atherogenesis and presents NOD receptors as essential
mediators of inflammation. Further studies will be needed in the future to examine the
role of NLRs in atherosclerosis in detail.
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Dates
Created: 2022Issued: 2022-07-04Updated: 2022-07-04
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
DFG-subjects
MakrophagenNOD RezeptorenNOD-SignalingLipidmetabolismusAtherosklerose
DDC-Numbers
610
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Shahin, Kinan: Rolle des NOD-Signalings innerhalb des Makrophagen Lipidmetabolismus. : Philipps-Universität Marburg 2022-07-04. DOI: https://doi.org/10.17192/z2022.0211.