Item type:Thesis, Open Access

Durch interne Emitter verursachte strahleninduzierte Nephropathie: Dosis-Effektbeziehungen, Prophylaxe und Therapie im präklinischen Modell der Radiopeptidtherapie neuroendokriner Tumoren

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Date

2004-12-30

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Philipps-Universität Marburg
DOI

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Abstract

Radiopeptide therapies are used in the treatment of malignant tumors, such as the medullary thyroid carcinoma or the SCLC. Radiolabeled Minigastrin is able to locate metastasis in an earlier state then it is possible with other diagnostic methods. The dose-limiting organ is the kidney. In such therapies a radiation nephropathy may result using higher activities. Prophylaxis is more important then treatment. The extent of a radiation-induced nephropathy varies depending on the used emitter. Auger/conversion-electron (e.g. 111In)emitters are high-LET emitters with a very short path length and do less harm to the radiosensitive structures of the kidney then ß- or a-emitters. Antioxidant substances may play an important role as well. Amifosin and selenide have a protective effect, other vitamins (A,C,E) do not significantly effect the developing of a radiation nephropathy. Drugs affecting the renin-angiotensin-system will lead to a more severe form of radiation nephropathy, when they are given after the radiation.

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Dates
Created: 2003Issued: 2004-12-30Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2004.0664
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Radiation nephropathy
DFG-subjects
Strahleninduzierte Nephropathie
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2004.0664
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Kluge, Gerald: Durch interne Emitter verursachte strahleninduzierte Nephropathie: Dosis-Effektbeziehungen, Prophylaxe und Therapie im präklinischen Modell der Radiopeptidtherapie neuroendokriner Tumoren. : Philipps-Universität Marburg 2004-12-30. DOI: https://doi.org/10.17192/z2004.0664.

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This item has been published with the following license: In Copyright