Item type:Doctoral Thesis, Open Access

Einfluss einer perioperativen analgetischen Therapie mit Parecoxib/Valdecoxib und/oder Paracetamol auf das Outcome nach Mammaoperationen

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Date

2010-10-26

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Philipps-Universität Marburg
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Abstract

In a randomized controlled trial we analyzed the influence of a perioperative analgesic therapy with Parecoxib/Valdecoxib and/or Paracetamol on outcome after breast surgery. 160 patients were randomized in a double blind manner to receive either Parecoxib/Valdecoxib, Paracetamol or the combination of both. The therapy was started intravenously and continued in a peroral way. Piritramid was used as rescue medication. We analyzed different aspects of patient satisfaction and quality of life (SF12 and PPP33-questionaire), opioid consumption and adverse events. All groups showed comparable high levels of patient satisfaction, low pain scores and opioid consumption. Differences in opioid consumption were regarded as non-significant; also there were no differences in adverse events. The combination of the Paracetamol and Parecoxib/Valdecoxib showed no advantage over the single substance use.

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Dates
Created: 2010Issued: 2010-10-26Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2010.0581
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
OutcomeParacetamolAcetaminophenPerioperativeParecoxibBreast surgeryValdecoxibPain therapyPerioperativOutcome
DFG-subjects
AnalgesieSchmerztherapieAnästhesieParecoxibParacetamol
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2010.0581
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Arndt, Christian (100416934): Einfluss einer perioperativen analgetischen Therapie mit Parecoxib/Valdecoxib und/oder Paracetamol auf das Outcome nach Mammaoperationen. : Philipps-Universität Marburg 2010-10-26. DOI: https://doi.org/10.17192/z2010.0581.

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