Item type:Doctoral Thesis, Open Access

Die Röntgenstrukturen der Glutamatdehydrogenase von Plasmodium falciparum und der Liponamiddehydrogenase von Trypanosoma cruzi. Zielmoleküle für das strukturbasierte Design neuer antiparasitärer Wirkstoffe

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Date

2008-06-24

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Philipps-Universität Marburg
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Abstract

In the work presented, the crystal structures of Plasmodium falciparum glutamate dehydrogenase (GDH) and of Trypanosoma cruzi Lipoamide dehydrogenase (LipDH) were determined to a resolution of 2.7 and 1.9 Angstroms, respectively. Both are targets for the design of novel antiparasitic drugs, because they are involved in the parasites defense against oxidative stress or in the production of reactive oxygen species (in the case of lipoamide dehydrogenase). The work also deals with the similarities and differences of the two parasite enzymes compared to closely related proteins and the respective proteins of the human host. The results provide a starting point for further studies with the aim to find selective inhibitors of P. falciparum GDH and improved so-called subversive substrates of T. cruzi LipDH with methods of structure-based drug design.

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Dates
Created: 2008Issued: 2008-06-24Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2008.0158
Faculty
Fachbereich Pharmazie
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Glutamate dehydrogenaseChagas DiseaseOxidative StressTropical MalariaLipoamide dehydrogenaseLiponamiddehydrogenase
DFG-subjects
Chagas-KrankheitKristallstrukturGlutamatdehydrogenaseTrypaMalaria tropicaOxidativer StressPlasmodium falciparumArzneimitteldesign
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2008.0158
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Werner, Christof (135755956): Die Röntgenstrukturen der Glutamatdehydrogenase von Plasmodium falciparum und der Liponamiddehydrogenase von Trypanosoma cruzi. Zielmoleküle für das strukturbasierte Design neuer antiparasitärer Wirkstoffe. : Philipps-Universität Marburg 2008-06-24. DOI: https://doi.org/10.17192/z2008.0158.

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