Item type:Thesis, Open Access

Erfassung von Acetylsalicylsäure Non-Responder mittels Platelet Function Analyser (PFA-100) und Risikofaktoren nach ischämischem Insult bei geriatrischen Patienten

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Date

2013-08-14

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Philipps-Universität Marburg
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Abstract

The aim of our investigation was to case study patients after a first ischemic stroke or a stroke recurrence to identify the chemical laboratory non-responders to acetylsalicylic acid (i.e. lack of inhibition of platelet aggregation in ex vivo - in vitro assay) and compare to clinical non-responders. The risk factors for stroke also formed part of the study.A total of 71 patients were examined, 53 had the first event of an ischemic insult, and 18 stroke recurrence. All except one patient showed an arterial hypertension. A total of 20 patients had diabetes mellitus. 26 patients were diagnosed with hyperlipidemia. Patients with prolonged closure time in the collagen / epinephrine cell (normal range: 85-165 sec) were defined as responders to acetylsalicylic acid. We found 14 (19.7%) non-responders.

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Dates
Created: 2013Issued: 2013-08-14Updated: 2013-08-14
DOI
https://doi.org/10.17192/z2013.0502
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
PFA-100ischemic strokeAspirinPFA-100
DFG-subjects
SchlaganfallAcetylsalicylsäure
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2013.0502
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Nosul, Matylda (1038838312): Erfassung von Acetylsalicylsäure Non-Responder mittels Platelet Function Analyser (PFA-100) und Risikofaktoren nach ischämischem Insult bei geriatrischen Patienten. : Philipps-Universität Marburg 2013-08-14. DOI: https://doi.org/10.17192/z2013.0502.

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This item has been published with the following license: In Copyright