Mikrosatelliteninstabilität und Mismatch-Repairgenexpression in Adenomen bei erblichen Dickdarmkarzinom (HNPCC)
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Philipps-Universität Marburg
Abstract
Among the malignant diseases of the gastro-intestinal (GI) tract, the hereditary
non-polyposis colorectal cancer (HNPCC) builds the largest group of hereditary
tumor diseases, with percentages ranging from with 2-5% up to 30%, depending
on the study. The (HNPCC) seems to be a polymorphic inherited disease;
despite progress, diagnosis is still difficult. The large variability of prevalences in
epidemiological studies results from these diagnostic difficulties. Diagnosis is
based on the anamnesis, initially developed 1913 by A. Warthin and later refined
by the Amsterdam– and Bethesda-Criteria.
The advantage of a carcinoma in the GI-tract is that it proceeds in several steps
from normal tissue over adenoma up to the final stage of a carcinoma.
Accordingly, an adenoma could help to predict a future carcinoma.
Adenoma might bear the key to the problems described above, and they are
relatively easy to examine using coloscopy, but at the moment they are not
adequately examined.
This study aims at examining temporal, immuno-histochemical and histological
perspectives of adenoma and their microsatellite status in patients with a HNPCC diagnosis.
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This item has been published with the following license: In Copyright