Niedrig-frequente repetitive transkranielle Magnetstimulation (rTMS) über Vertex in der Migräneprophylaxe
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Philipps-Universität Marburg
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Abstract
High-frequency repetitive transcranial magnetic stimulation (rTMS) increases
and low-frequency rTMS decreases neural excitability. Clinically, rTMS shows
beneficial effects in the treatment of neurological and psychiatric disorders.
Furthermore, chronic and neuropathic pain has been shown to respond to rTMS
treatment. A small pilot study revealed prophylactic effects of high-frequency
rTMS in migraine. As there is evidence of neuronal hyperexcitability in migraine, we conducted a placebo-controlled, blinded study to evaluate the therapeutic effects of low-frequency rTMS in migraine. The primary end-point was defined as a reduction of migraine attacks compared with placebo, secondary outcomes were a reduction in the total number of days with headache, hours with
headache, pain intensity and a decrease of analgesic intake for migraine. Twentyseven migraineurs completed the study and were treated with rTMS on five
consecutive days. For the verum group, two trains of 500 pulses with a frequency
of 1 Hz were applied over vertex with a round coil. For the treatment of the
placebo group, a figure-of-eight sham coil was used. A significant decrease of
migraine attacks could be observed in the verum group. However, when
comparing these effects with placebo, no significance was evident. The same was
true concerning secondary outcome measures with regard to days with migraine
and total hours with migraine. No effects were evident for pain intensity and use of analgesics. The rTMS treatment was tolerated well. rTMS stimulation over
vertex with 1 Hz was not effective in migraine prophylaxis when compared with
placebo. The positive effects regarding migraine attacks, days and total hours
with migraine in the verum group are encouraging and indicate that further
research on this topic is warranted.
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Created: 2010Issued: 2010-07-08Updated: 2011-08-10
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
MigraineSchmerzVertexLow-frequency rTMSProphylactic treatment
DFG-subjects
ProphylaxeVertexMigräneNiedrig-frequente transkranielle Magnetstimulation
DDC-Numbers
610
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Hötzel, Jenny: Niedrig-frequente repetitive transkranielle Magnetstimulation (rTMS) über Vertex in der Migräneprophylaxe. : Philipps-Universität Marburg 2010-07-08. DOI: https://doi.org/10.17192/z2010.0379.
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This item has been published with the following license: In Copyright