Item type:Thesis, Open Access

Parameterbildung zur Durchblutungsquantifizierung der unteren Extremität mittels dynamischer Kernspintomographie

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Date

2010-01-26

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Philipps-Universität Marburg
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Abstract

This study describes the potential of dynamic contrast- enhanced magnetic resonance tomography (DCE-MRT) for the visualization and quantification of blood flow of lower leg muscles at rest and after muscular exercise both in healthy people as well as in patients with peripheral arterial occlusive disease. Parameters are to be found that represent the blood circulation situation in the lower leg. Following it should be examined whether they also reflect the blood circulation situation in patients with peripheral arterial occlusive disease and allow thus statements about the hemodynamic relevance of Stenosis. The well reproducible parameters used were mean intesio to time ratio (MITR), mean transit time (MTT), time to peak (TTP), Slope, Integral und peak enhancement (PE). We compared then before and after exercise and before and after balloon angioplasty of the crural artery . All Parameters exept for integral and PE allowed for a clear distinction between before and after exercise as well as between strongly and less strongly stressed muscles. It can be concluded, the more steeply the initial curve rises, the higher the peak and the faster the curve falls, the better is the muscular blood circulation. This is particularly clear after exercise. The study showed that the DCE MRT has a diagnostic potential for the evaluation of the peripheral blood circulation in the lower leg. The parameters represent a change of the blood circulation situation both after exercise and after balloon angioplasty of the crural artery.

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Dates
Created: 2009Issued: 2010-01-26Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2009.0734
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Magnetic Resonance ImagingAngioplastyTissue perfusionArterial Occlusive Diseases
DFG-subjects
Körperliche BelastungPeriphere arterielle VerschlusskrankheitPerkutane transluminale AngioplastieDurchblutungsmessungNMR-Tomographie
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2009.0734
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Handzel, Elisabeth: Parameterbildung zur Durchblutungsquantifizierung der unteren Extremität mittels dynamischer Kernspintomographie. : Philipps-Universität Marburg 2010-01-26. DOI: https://doi.org/10.17192/z2009.0734.

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This item has been published with the following license: In Copyright