Der Einfluss der psychopharmakologischen Behandlung auf die Gestikverarbeitung bei Patient:innen mit Schizophrenie, Depression und Bipolarer Störung
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Abstract
As social beings, humans are dependent on communication by means of language, which is often accompanied by gestures. The ability to interact successfully with others, including the processes of gesture production and perception, is severely im-paired in various mental illnesses, which significantly restricts the social life and qua-lity of life of those affected. In schizophrenia in particular, gesture processes play a major role in the course and symptom severity of the illness. This study was the first to investigate the cross-diagnostic relationships between psychopharmacological trea-tment and gesture processing in patients with schizophrenia, depression and bipolar disorder. In particular, possible effects of antipsychotics were analysed in more detail. To this end, data from 133 patients aged between 18 and 62 years was analysed, which was collected at Marburg University Hospital between 2015 and 2020. For an objective gesture assessment, the subjects performed a speech-gesture matching task in which the patients had to push a button to indicate whether the arm and hand gestures played in a video clip were appropriate or inappropriate for the speech content. The subjective gesture self-assessment was carried out using the "Brief Assessment of Gestures" (BAG), which contains twelve statements on gesture behaviour. Demographic and cli-nical variables on symptoms and medication were also collected, which were used to calculate the individual equivalent doses for antipsychotics and antidepressants, as well as prescription binding profiles and side effect profiles.
It was found that patients taking atypical neuroleptics performed worse in the speech-gesture matching task than patients receiving other therapies (p < 0.001). After con-trolling for the influence of confounding factors (such as diagnosis, symptoms and side effects), such a correlation was only found a trend level (p = 0.093). In addition, a higher neuroleptic equivalent dose was also associated with poorer performance in the speech-gesture matching task (p < 0.001), which was no longer detectable after con-trolling for confounding factors (p = 0.055). However, exploratory results still showed significant correlations between the psychopharmacological treatment and the results in the gesture task and the questionnaire. From this we conclude that there are effects of medication on gesture processing, but these cannot be clearly separated from the influence of other factors such as diagnosis, symptoms and side effects. Further stu-dies need to be conducted in the future to prove possible causal relationships and con-firm our findings.
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Issued: 2025-10-01
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Has part: straube
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FB20:Medizin
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de
Keywords
GestikSchizophrenieDepressionBipolare StöungGestikverarbeitungGestikwahrnehmungGestikproduktionBrief Assessment of GesturePsychopharmakologieAntipsychotikaAntidepressivasoziale Interaktion
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2.23-10 - Klinische Psychiatrie, Psychotherapie und Kinder- und Jugendpsychiatrie
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Gürtler, Cara: Der Einfluss der psychopharmakologischen Behandlung auf die Gestikverarbeitung bei Patient:innen mit Schizophrenie, Depression und Bipolarer Störung. : 2025-10-01.
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