Item type:Thesis, Open Access

Lymphozytensubpopulationen bei nierentransplantierten Kindern - Langzeitveränderungen nach Induktionstherapie mit polyklonalen Antilymphozytenantikörpern

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2004-12-30

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Philipps-Universität Marburg
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Abstract

BACKGROUND: T-cell depletion causes a novel homeostasis in lymphocyte subsets in adult transplant recipients. Little is known about long-term changes in pediatric patients. METHODS: Twenty-one pediatric renal-transplant patients (mean age 11.8 years) were selected according to their initial postoperative immunosuppressive therapy: (1) baseline immunosuppression (BI) with cyclosporine, azathioprine, and steroids, n=11; and (2) BI plus polyclonal antibodies, n=10. Lymphocyte surface markers were measured in the mean 2.3 years after transplantation and analyzed between the patient groups and in regard to 46 age-matched healthy controls. RESULTS: The patient groups did not differ with respect to age, sex, renal function, and previous infections. Total lymphocyte counts, CD4+ T-cell numbers, and distribution of naive to memory CD4+ T cells were not different between transplant groups and controls. However, patients with postoperative T-cell depletion showed significantly lower ratios of CD4+ to CD8+ T cells, elevated CD8+ T-cell numbers, increased counts of CD8+ T cells coexpressing CD57, and higher numbers of CD8+ cells with a naive phenotype. In addition, the numbers of double-positive T cells and lymphocytes bearing both natural killer (NK) and T-cell markers were elevated in the patients with postoperative depletion. NK and B-cell counts were lower in the transplant patient groups compared with the healthy controls. CONCLUSIONS: Pediatric transplant patients show characteristic long-term changes in lymphocyte subsets after T-cell depletion. In contrast with adult patients, these perturbations are less pronounced and predominant in the CD8+ T-cell compartment.

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Dates
Created: 2004Issued: 2004-12-30Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2004.0661
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
NierentransplantationPhenotypesT-Zell-DepletionAntilymphozytäre AntikörperT cell depletionImmune reconstitutionLymphozytensubpopulationenPediatric transplantation
DFG-subjects
Lymphozytenantigen
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2004.0661
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Mostert, Marthe Katharina: Lymphozytensubpopulationen bei nierentransplantierten Kindern - Langzeitveränderungen nach Induktionstherapie mit polyklonalen Antilymphozytenantikörpern. : Philipps-Universität Marburg 2004-12-30. DOI: https://doi.org/10.17192/z2004.0661.

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This item has been published with the following license: In Copyright