Glioblastoma multiforme (GBM) is the most prevalent primary brain tumor in adults, exhibiting highly invasive growth patterns and dismal prognosis. Consequently, the development of new therapeutic measures remains an important issue. In this regard, the tumor microenvironment (TME), which consists of a complex network of tumor-associated cells, has garnered increased attention. The objective of this thesis was to further elucidate the role of A disintregrin and metalloprotease 8 (ADAM8) in the GBM tumor microenvironment. This investigation was undertaken because the expression of ADAM8 in GBM is associated with tumor invasiveness.
Consequently, the expression of ADAM8 was observed in both human GBM-tissue and glioma tissue derived from mouse models. This observation was made in different cell types, suggesting that ADAM8 ist not only present in tumor cells but also in immune-competent cells of the GBM tumor microenvironment.
Consequently, ADAM8 has the potential to fulfill a pivotal function in the reciprocal intercations between the various cell types, thereby promoting the development of GBM.
Käßer, Vanessa: Analyse der Bedeutung von ADAM8 für die Glioblastom-Mikroumgebung anhand eines Mausmodells. : Philipps-Universität Marburg 2025-08-11. DOI: https://doi.org/10.17192/z2025.0419.