3-Center Studie zur Untersuchung von Auswirkungen der Ganzkörpervibrationstherapie bei Patienten mit Lungenfibrose: eine randomisiert kontrollierte Studie. Effekte auf serumspezifische Biomarker, Inflammationsparameter, gesundheitsbezogene Lebensqualität und den 6-Minutengehtest als Nebenergebnis.
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Abstract
Background: Numerous studies reported positive effects of exercise training in patients with interstitial lung disease (ILD) on physical capacity, lung function and quality of life. However, evidence is rare on effects of specific forms of training and pathophysiological mechanisms in these patients. In this German three-centre study (Marburg, Heidelberg, Wangen) it is aimed to explore clinical effects of whole-body vibration training (WBVT) in patients with ILD and various outcome measures including proinflammatory cytokines and muscle related biomarkers.
Methods: We randomly assigned 26 patients with different forms of multidisciplinary discussed ILD to the training group (n:11; m:6; f:5; y: 62 [49;74]) performing three months of a standardized training and 15 patients with ILD (n: 15; m:9; f:6; y: 63 [55;69]) to the control group (CTG) performing sham-training. 3-Months WBV Training was performed on a Galileo device, and for sham training a reduced frequency of (5 Hz) was applied. Functional assessments before and after 3 months of training included a 6-Minute-Walk-Test (6 MWD), Chair-Rising-Test, ultrasonographic measurement of Quadriceps Muscle Thickness (cross-sectional area), lung functional parameters, Quality of Life Questionnaires and Serum Samples.
Results: We observed a significantly longer 6-minute walk distance (6-MWD) (∆Training=30.0m [12,67], p=0.024) and a decrease of Myostatin (∆Training=-464.8.pg/ml [-713, -166.3], p=0.008) in the WBV group. Group comparison showed significances of 6-MWT, Myostatin and IL-6 (6-MWT: ∆Control=4,0m [-9;20], p=0,026; Myostatin: ∆Control=150,4 pg/ml [-305,6; 473,5], p=0,009; IL-6: ∆Training=-1.00pg/ml vs. ∆Control=0.00pg/ml, p=0.036). All three parameters remained unchanged in controls, whereas no differences in lung functional parameters, the Chair-Rising-Test, femoral muscle area, quality of life and other serum markers were observed.
Conclusion: The present study demonstrates a positive effect of WBV on 6-MWT and levels of muscle-related serum marker myostatin in patients with ILD. Improvement of 6-MWD might reflect a clinically significant benefit in muscular performance while the decrease in myostatin may give a clue to physiological mechanisms of WBV. There is no clear interpretation of IL-6 results, but they might show an intervention-related stabilization of the inflammation marker. WBVT consequently seems to be a beneficial and feasible training modality in ILD patients.
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Created: 2020Issued: 2020-04-16Updated: 2020-04-16
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
3-Center-Study3-Center-Studierandomisiert-kontrolliertwhole-body-vibration traininmulti-center studyrandomized-controlledInterstitial lung diseasefibrosierende interstitielle Lungenerkrankungfibrotic interstitial lung diseaseGanzköMulticenter-StudieInterstitielle Lungenerkrankung
DFG-subjects
BiomarkerLungenfibroseMuskelkraftLebensqualitätLungenkrankheitRehabilitationInterstitielle Lungenkrankheit
DDC-Numbers
610
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Kölpin, Janina: 3-Center Studie zur Untersuchung von Auswirkungen der Ganzkörpervibrationstherapie bei Patienten mit Lungenfibrose: eine randomisiert kontrollierte Studie. Effekte auf serumspezifische Biomarker, Inflammationsparameter, gesundheitsbezogene Lebensqualität und den 6-Minutengehtest als Nebenergebnis.. : Philipps-Universität Marburg 2020-04-16. DOI: https://doi.org/10.17192/z2020.0175.