Experimentelle bandförmige Keratopathie nach intrakameraler Injektion von Phosphatpufferlösung
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Philipps-Universität Marburg
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Abstract
Calcific band-shaped keratopathies are characterised by calcium deposits in Bowman´s membrane and in the superficial stromal layers of the cornea. They occur from localized ocular inflammatory disease and from systemic disease that causes hypercalcemia and/or hyperphosphatemia. Local application of phosphate-containing eye drops as well as intracameral phosphate-containing irrigation solutions are further mentioned to cause corneal calcification.
Intracameral r-TPA (recombinant tissue plasminogen activator) sometimes causes irreversible corneal calcification. Whether the phosphate-containing buffer to r-TPA or r-TPA itself is responsible for corneal calcification has not been tested to date.
The aim of this study was to observe the effects on the cornea following intracameral injection of phosphate buffer and the importance of the structural integrity of the corneal endothelium.
The anterior chambers of rabbit eyes were injected with phosphate buffer of different concentrations. To examine a possible effect of an endothelial dysfunction, a circumscribed mechanical lesion of the corneal endothelium was performed in a defined manner on a second group. The control group only received the endothelial lesion. Slit lamp examinations were performed over a period of one month followed by histological examination of representative specimen. Calcium deposits were proven by von Kossa staining.
Corneal calcifications occurred in eyes with and without mechanical endothelial lesion. Deposits of calcium salts were found subepithelial and in the superficial stromal layers of the cornea. In eyes with an endothelial lesion the total amount of phosphate needed to cause an opacification might be slightly lower than in eyes without endothelial injury.
Corneal calcification can be caused by intracameral injection of phosphate buffer. A mechanical lesion of the corneal endothelium is not required. In eyes with an endothelial lesion the total amount of phosphate needed to cause an opacification may be slightly lower than in eyes without endothelial injury.
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Created: 2006Issued: 2006-10-05Updated: 2011-08-10
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Bandförmige KeratopathieHornhauttrübungPhosphatpufferCorneaBand-shaped keratopathyCorneal opacificationPhosphate
DFG-subjects
TrübungVerkalkungPhosphateAugeHornhaut
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610
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Büning, Christoph (132137771): Experimentelle bandförmige Keratopathie nach intrakameraler Injektion von Phosphatpufferlösung. : Philipps-Universität Marburg 2006-10-05. DOI: https://doi.org/10.17192/z2006.0690.
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This item has been published with the following license: In Copyright