Item type:Thesis, Open Access

Transcriptional Control Mechanisms of the Uncoupling Protein 3 Gene and their Functional Implications

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Date

2008-01-10

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Philipps-Universität Marburg
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Abstract

All proposed hypotheses regarding the physiological function of Ucp3 are at least in part based on the transcriptional regulation of this gene. This fact illustrates how important knowledge of the regulation of a gene is to be able to infer its role. Our mutant hamster model, however, could not be fully explained by the existing model of transcriptional control and thereby challenged its integrity. During my PhD study period I addressed open questions on Ucp3 regulation employing two parallel approaches. On the one hand our mutant hamster model served as a tool to identify the unknown regulatory pathway affected by this mutation. On the other hand an unbiased analysis of the hamster Ucp3 promoter aimed at the identification and verification of so far unknown transcription factor binding sites.

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Dates
Created: 2007Issued: 2008-01-10Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2007.0785
Faculty
Fachbereich Biologie
Publisher
Philipps-Universität Marburg
Language
eng
Data types
DoctoralThesis
Keywords
TranscriptionUcp3Brown adipose tissueSkeletal muscleUncoupling protein
DFG-subjects
Entkoppler-ProteineSkelettmuskelMitochondrial Uncoupling Protein 3Braunes FettgewebeGenregulation
DDC-Numbers
570
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2007.0785
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Fromme, Tobias: Transcriptional Control Mechanisms of the Uncoupling Protein 3 Gene and their Functional Implications. : Philipps-Universität Marburg 2008-01-10. DOI: https://doi.org/10.17192/z2007.0785.

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This item has been published with the following license: In Copyright