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Date
2025-10-21
Authors
Publisher
Philipps-Universität Marburg
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Abstract
Allergic rhinitis is a global health problem. The prevalence of allergic rhinitis is constantly growing. An early diagnosis and an adequate therapy are important to ensure the quality of life is affected as little as possible and to prevent comorbidities such as bronchial asthma. The diagnostic investigation of allergic rhinitis is often lengthy and shows inconclusive results.
In the present study, a non-invasive analysis of volatile organic compounds in the exhalation air was shown to present an innovative method for diagnosing allergic rhinitis: the exhalation air of 15 patients suffering from allergic rhinitis and 19 healthy subjects was analyzed by Cyranose320. Prior to this, a blood analysis was performed to determine the concentration of total Immunglobulin E and allergen-specific Immunglobulin E for birch pollen, timothy pollen, house dust mites, wasp venom and bee venom. Patients in the allergy cohort were also investigated by a skin prick test.
The results of the volatile organic compounds measurements were evaluated by multivariate analysis methods. A mahalanobis distance of 1.96 was rated as significant. A comparison of the allergy cohort and the healthy subjects, per-formed on the basis of clinical history and serological results, resuted in a mahalanobis distance of 1.193, allowing a non-significant separation of the cohorts. When considering the allergen-specific Immunglobulin E the cohorts could be distinguished even more precisely with a mahalanobis distance of 1,511. Comparing individuals on the basis of allergen-specific Immunglobulin E carrier-polymer-system-classes or severities of clinical symptoms a significant distinction between the groups could partially be made.
Thus, there was a trend for different exhalation air profiles of patients with allergic rhinitis and healthy controls analyzed by Cyranose320. Further investigations with a larger sample size of patients and control subjects seem to be worthwhile to obtain more definite results.
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Dates
Created: 2025Issued: 2025-10-21Updated: 2025-10-21
Faculty
Medizin
Language
ger
Data types
DoctoralThesis
Keywords
electronic noseAllergiediagnostikelektronische Naseallergy
DFG-subjects
Volatile organic compoundseNosePollenallergieAllergyCyranoseAllergiediagnostikElektronische NaseVOCs
DDC-Numbers
610
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Lortz, Christine: Detektion einer Pollenallergie durch eine elektronische Nase. : Philipps-Universität Marburg 2025-10-21. DOI: https://doi.org/10.17192/z2025.0542.
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This item has been published with the following license: In Copyright